To determine and implement optimal management, treatment is often guided by a multidisciplinary team of cancer specialists who have experience treating childhood brain tumors.
In infants and young children, low-grade astrocytomas presenting in the hypothalamus make surgery difficult; consequently, biopsies are not always done. This is especially true in patients with neurofibromatosis type 1 (NF1). When associated with NF1, tumors may be of multifocal origin.
Since you were recently diagnosed with a brain tumor, ask your doctor these questions at your next visit.
1. What type of brain tumor do I have, and what is its grade?
2. What are the symptoms of brain cancer?
3. What part of my brain is affected by the tumor and what does this region of the brain do?
4. Will it be possible to surgically remove my tumor?
5. Will I need any other treatments such as chemotherapy or radiotherapy after surgery?
6. What are the possible side effects of these therapies?
Observation is an option for patients with NF1 or nonprogressive masses.[4,5,6,7] Spontaneous regressions of optic pathway gliomas have been reported in children with and without NF1.[8,9,10]
Surgical resection is the primary treatment for childhood low-grade astrocytoma [1,4,5,11] and surgical feasibility is determined by tumor location.
Cerebellum: Complete or near-complete removal can be obtained in 90% to 95% of patients with pilocytic tumors that occur in the cerebellum.
Optic nerve: For children with isolated optic nerve lesions and progressive symptoms, complete surgical resection, while curative, generally results in blindness in the affected eye.
Midline structures (hypothalamus, thalamus, brain stem, and spinal cord): Low-grade astrocytomas that occur in midline structures can be aggressively resected, with resultant long-term disease control;[8,9,12]; [Level of evidence: 3iiiA] however, such resection may result in significant neurologic sequelae, especially in children younger than 2 years at diagnosis.; [Level of evidence: 3iC] Because of the infiltrative nature of some deep-seated lesions, extensive surgical resection may not be appropriate and biopsy only should be considered.[Level of evidence: 3iiiDiii]
Cerebrum: Circumscribed, grade I hemispheric tumors are often amenable to complete surgical resection.
Diffuse: Diffuse astrocytomas may be less amenable to total resection, and this may contribute to the poorer outcome.