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Childhood Astrocytomas Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Treatment Option Overview for Childhood Astrocytomas

Table 4. Standard Treatment Options for Childhood Astrocytomas

Grade/StageStandard Treatment Options
Childhood low-grade astrocytomas: 
 Newly diagnosed childhood low-grade astrocytomasObservation
Surgery
Adjuvant therapy(for tumors that are incompletely resected):
 Observation
Radiation therapy
Second surgery
Chemotherapy
Targeted therapy(for subependymal giant cell astrocytomas)
 Recurrent childhood low-grade astrocytomasSecond surgery
Radiation therapy
Chemotherapy
Childhood high-grade astrocytomas: 
 Newly diagnosed childhood high-grade astrocytomasSurgery
Adjuvant therapy:
 Radiation therapy
Chemotherapy
 Recurrent childhood high-grade astrocytomasHigh-dose, marrow-ablative chemotherapy with hematopoietic stem cell transplant(not considered standard treatment)
Novel therapeutic approaches(not considered standard treatment)

References:

  1. Packer RJ, Sutton LN, Atkins TE, et al.: A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results. J Neurosurg 70 (5): 707-13, 1989.
  2. Johnson DL, McCabe MA, Nicholson HS, et al.: Quality of long-term survival in young children with medulloblastoma. J Neurosurg 80 (6): 1004-10, 1994.
  3. Packer RJ, Sutton LN, Goldwein JW, et al.: Improved survival with the use of adjuvant chemotherapy in the treatment of medulloblastoma. J Neurosurg 74 (3): 433-40, 1991.
  4. Bowers DC, Mulne AF, Reisch JS, et al.: Nonperioperative strokes in children with central nervous system tumors. Cancer 94 (4): 1094-101, 2002.
  5. Duffner PK, Horowitz ME, Krischer JP, et al.: Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med 328 (24): 1725-31, 1993.

This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

WebMD Public Information from the National Cancer Institute

Last Updated: May 28, 2015
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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