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    Childhood Ependymoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Treatment Option Overview for Childhood Ependymoma

    Many of the improvements in survival in childhood cancer have been made as a result of clinical trials that have attempted to improve on the best available, accepted therapy. Clinical trials in pediatrics are designed to compare new therapy with therapy that is currently accepted as standard. This comparison may be done in a randomized study of two treatment arms or by evaluating a single new treatment and comparing the results with those previously obtained with existing therapy.

    Because of the relative rarity of cancer in children, all patients with aggressive brain tumors should be considered for entry into a clinical trial. To determine and implement optimum treatment, treatment planning by a multidisciplinary team of cancer specialists who have experience treating childhood brain tumors is required. Radiation therapy of pediatric brain tumors is technically demanding and should be performed in centers that have experience in that area to ensure optimal results.

    Table 1. Standard Treatment Options for Childhood Ependymoma

    Stage and/or Histopathologic Classification Standard Treatment Options
    Newly diagnosed childhood subependymoma Surgery
    Observation (in rare cases)
    Newly diagnosed childhood myxopapillary ependymoma Surgery with or without radiation therapy
    Newly diagnosed childhood ependymoma (WHO Grade II) or anaplastic ependymoma (WHO Grade III): Surgery
    Adjuvant therapy:
    No residual disease, no disseminated disease Radiation therapy
    Residual disease, no disseminated disease Second-look surgery
    Radiation therapy
    Preirradiation chemotherapy
    Central nervous system disseminated disease Radiation therapy
    Children younger than 3 years Chemotherapy
    Radiation therapy
    Recurrent childhood ependymoma Surgery
    Radiation therapy and/or chemotherapy

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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