Endometrial Cancer Screening (PDQ®): Screening - Health Professional Information [NCI] - Stages of Gestational Trophoblastic Tumors and Neoplasia
After gestational trophoblastic neoplasia has been diagnosed, tests are done to find out if cancer has spread from where it started to other parts of the body. The process used to find out the extent or spread of cancer is called staging, The information gathered from the staging process helps determine the stage of disease. For GTN, stage is one of the factors used to plan treatment.The following tests and procedures may be done to help find out the stage of the disease: Chest x-ray: An x-ray of the organs and bones inside the chest. An x-ray is a type of energy beam that can go through the body onto film, making pictures of areas inside the body.CT scan (CAT scan): A procedure that makes a series of detailed pictures of areas inside the body, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography,
Cervical Cancer Prevention (PDQ®): Prevention - Patient Information [NCI] - Cellular Classification of Uterine Sarcoma
The most common histologic types of uterine sarcomas include:Carcinosarcomas (mixed mesodermal sarcomas [40%–50%]).Leiomyosarcomas (30%).Endometrial stromal sarcomas (15%).The uterine neoplasm classification of the International Society of Gynecologic Pathologists and the World Health Organization uses the term carcinosarcomas for all primary uterine neoplasms containing malignant elements of both epithelial and stromal light microscopic appearances, regardless of whether malignant heterologous elements are present.References: Silverberg SG, Major FJ, Blessing JA, et al.: Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus. A Gynecologic Oncology Group pathologic study of 203 cases. Int J Gynecol Pathol 9 (1): 1-19, 1990.
Gestational Trophoblastic Disease Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Treatment Option Overview
Most hydatidiform moles (HMs) are benign and are treated conservatively by dilation, suction evacuation, and curettage. However, since they carry a risk of persistence or progression to malignant gestational trophoblastic disease (GTD), they must be followed carefully with weekly serum human chorionic gonadotropin (hCG) levels to normalization. Monthly follow-up for 6 months is generally recommended, although the duration of this phase of follow-up is not based on empiric study.Prompt institution of therapy for GTD and continuing follow-up at very close intervals until normal beta-hCG titers are obtained is the cornerstone of management. When chemotherapy is instituted, the interval between courses should rarely exceed 14 to 21 days, depending on the regimen used. It is recommended that patients receive one to three courses of chemotherapy after the first normal beta-hCG titer, depending on the extent of disease. The modified World Health Organization (WHO) Prognostic Scoring System
Endometrial Cancer Screening (PDQ®): Screening - Health Professional Information [NCI] - Stage IV Uterine Sarcoma
There is currently no standard therapy for patients with stage IV disease. These patients should be entered into an ongoing clinical trial.Carcinosarcomas (the preferred designation by the World Health Organization) are also referred to as mixed mesodermal or mullerian tumors. Controversy exists about the following issues:Whether they are true sarcomas.Whether the sarcomatous elements are actually derived from a common epithelial cell precursor that also gives rise to the usually more abundant adenocarcinomatous elements. The stromal components of the carcinosarcomas are further characterized by whether they contain homologous elements, such as malignant mesenchymal tissue considered possibly native to the uterus, or heterologous elements, such as striated muscle, cartilage, or bone, which is foreign to the uterus. Carcinosarcomas parallel endometrial cancer in its postmenopausal predominance and in other of its epidemiologic features; increasingly, the treatment of carcinosarcomas
Endometrial Cancer Screening (PDQ®): Screening - Health Professional Information [NCI] - Treatment Option Overview
There are different types of treatment for patients with cervical cancer. Different types of treatment are available for patients with cervical cancer. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.Three types of standard treatment are used:Surgery Surgery (removing the cancer in an operation) is sometimes used to treat cervical cancer. The following surgical procedures may be used:Conization: A procedure to remove a cone-shaped piece of tissue from the cervix and cervical canal. A pathologist
Cervical Cancer Prevention (PDQ®): Prevention - Patient Information [NCI] - Placental-Site Gestational Trophoblastic Tumor Treatment
Given the rarity of this tumor, reports of therapeutic results are confined to relatively small case series with accrual extending for very long time periods. Therefore, few reliable comparisons among surgical approaches or chemotherapeutic regimens can be made. Nevertheless, there are distinctions in underlying biology between placental-site gestational trophoblastic tumors (PSTTs) and the other gestational trophoblastic tumors—particularly resistance to chemotherapy—that justify specific treatment strategies, such as the following: Tumors confined to the uterus (Féderation Internationale de Gynécologie et d'Obstétrique [FIGO] Stage I).Hysterectomy is the treatment of choice.[1,2] In a relatively large, retrospective, population-based, consecutive, case series of 62 women with PSTT, 33 had disease confined to the uterus and were treated with hysterectomy (n = 17) or with hysterectomy plus chemotherapy (n = 16). Overall survival at 10 years was virtually identical between the
Endometrial Cancer Screening (PDQ®): Screening - Health Professional Information [NCI] - Overview
Note: Separate PDQ summaries on Cervical Cancer Screening and Cervical Cancer Treatment are also available. Avoidance of Human Papillomavirus Infection Based on solid evidence,the following measures are effective to avoid human papillomavirus (HPV) infection,and thus cervical cancer: ABSTINENCE FROM SEXUAL ACTIVITY MAGNITUDE OF EFFECT: ABSTINENCE PREVENTS HPV INFECTION. Study Design: Evidence ...
Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Epithelioid Trophoblastic Tumor Treatment
These tumors are exceedingly rare. There is little information to guide therapy. However, they are similar in behavior and prognosis to placental-site trophoblastic tumors, so it is reasonable to manage them similarly. (Refer to the Placental-Site Gestational Trophoblastic Tumor Treatment section of this summary for more information.) Only a minority of these tumors are malignant in behavior, but they are not very responsive to systemic therapy. A variety of chemotherapy regimens have been used.Current Clinical TrialsCheck for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with epithelioid trophoblastic tumor. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.General information about clinical trials is also available from the NCI Web site.References: Palmer JE, Macdonald M, Wells M, et al.: Epithelioid trophoblastic tumor: a review of the literature. J Reprod Med 53 (7): 465-75,
Endometrial Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - General Information About Endometrial Cancer
Related Summaries Note: Other PDQ summaries containing information related to endometrial (uterine corpus) cancer include the following: Uterine Sarcoma Treatment Endometrial Cancer Screening Endometrial Cancer Prevention Statistics Note: Estimated new cases and deaths from endometrial (uterine corpus) cancer in the United States in 2010:[ 1 ] New cases: 43,470. Deaths: 7,950. Cancer of the ...
Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Questions or Comments About This Summary
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