How It Works
A woman's body makes the hormone
Progestin is the man-made form of progesterone.
It is usually given in pill
Hormone therapy works by blocking the action of hormones, which stops some types of cancer cells from growing. It only works with the type of cancer cells that respond to hormones. So before a woman is given this treatment, her cancer cells are tested to see if the treatment will work.
Why It Is Used
Progestin hormone therapy may be used to slow the growth of
endometrial cancer. This may be done when the cancer has spread to other parts of the body. Or it may be done for a young woman with early-stage cancer so she can become pregnant in the future.
How Well It Works
Progestin hormone therapy has been shown to slow cancer cell growth for up to 30 out of 100 women
who had advanced endometrial cancer. This therapy also helped to slow
cancer cell growth in women who had endometrial cancer that had come back after treatment.1
Progestin hormone therapy can cause side effects, including:
- Nausea or
- Mild shortness of
- Hot flashes or
- Decreased sex drive.
Serious side effects are rare but may include:
- Sudden severe
- Changes in eyesight.
- Numbness or swelling in
an arm or leg.
Progestin hormone therapy is also used as an appetite stimulant.
You may experience an increased appetite, which could result in weight
See Drug Reference for a full list of side effects. (Drug Reference
is not available in all systems.)
What To Think About
Progestin hormone therapy may be given to women who are unable to
have surgery or radiation therapy.
Women who have endometrial cancer that has spread to other parts
of the body may live longer if they receive progestin
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
National Cancer Institute (2012). Endometrial Cancer Treatment (PDQ)—Health Professional Version. Available online: http://www.cancer.gov/cancertopics/pdq/treatment/endometrial/HealthProfessional.
Primary Medical Reviewer
||Sarah Marshall, MD - Family Medicine
Specialist Medical Reviewer
||Ross Berkowitz, MD - Obstetrics and Gynecology
||November 27, 2012