Stage II Endometrial Cancer
Many combinations of preoperative intracavitary and external-beam radiation therapy (EBRT) with hysterectomy and bilateral salpingo-oophorectomy are used for treatment of stage II endometrial cancer, with careful biopsy of the para-aortic nodes at the time of surgery. When microscopic cervical stromal involvement is found, postoperative radiation therapy (EBRT and vaginal radiation therapy) should be used.
Stage IIA
Cervical dysplasia is a precancerous condition in which abnormal cell growth occurs on the surface lining of the cervix, the opening between the uterus and the vagina. Strongly associated with sexually transmitted human papillomavirus (HPV) infection, cervical dysplasia is most common in women under age 30 but can develop at any age. Cervical dysplasia usually causes no symptoms, and is most often discovered by a routine Pap test. The prognosis is excellent for women with cervical dysplasia who...
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Stage IIA (endocervical glandular involvement only) should be treated the same as stage I disease.
Stage IIB
Standard treatment options:
- Hysterectomy, bilateral salpingo-oophorectomy, and node sampling followed by postoperative radiation therapy.
- Preoperative intracavitary and EBRT followed by hysterectomy and bilateral salpingo-oophorectomy. (A biopsy of the para-aortic nodes should be done at the time of surgery.)
- Radical hysterectomy and pelvic lymphadenectomy in selected cases.
Current Clinical Trials
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage II endometrial carcinoma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
WebMD Public Information from the National Cancer Institute
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