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Endometrial Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular Classification of Endometrial Cancer

The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant glandular epithelial elements; an admixture of squamous metaplasia is not uncommon. Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium;[1] clear cell and papillary serous carcinoma of the endometrium are tumors that are histologically similar to those noted in the ovary and the fallopian tube, and the prognosis is worse for these tumors.[2] Mucinous, squamous, and undifferentiated tumors are rarely encountered. Frequency of endometrial cancer cell types is as follows:

  1. Endometrioid (75%–80%).
    1. Ciliated adenocarcinoma.
    2. Secretory adenocarcinoma.
    3. Papillary or villoglandular.
    4. Adenocarcinoma with squamous differentiation.
      1. Adenoacanthoma.
      2. Adenosquamous.
  2. Uterine papillary serous (<10%).
  3. Mucinous (1%).
  4. Clear cell (4%).
  5. Squamous cell (<1%).
  6. Mixed (10%).
  7. Undifferentiated.

References:

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Get More Information From NCI

Call 1-800-4-CANCER For more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 8:00 a.m. to 8:00 p.m., Eastern Time. A trained Cancer Information Specialist is available to answer your questions. Chat online The NCI's LiveHelp® online chat service provides Internet users with the ability to chat online with an Information Specialist. The...

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  1. Zaino RJ, Kurman R, Herbold D, et al.: The significance of squamous differentiation in endometrial carcinoma. Data from a Gynecologic Oncology Group study. Cancer 68 (10): 2293-302, 1991.
  2. Gusberg SB: Virulence factors in endometrial cancer. Cancer 71 (4 Suppl): 1464-6, 1993.

WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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