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    Treatments for Chronic Myelogenous Leukemia

    There are a lot of ways to treat chronic myelogenous leukemia (CML) that can help bring your disease under control. To find the best one for you, you'll work closely with a specialist called a hematologist-oncologist, a doctor with special training in blood diseases such as leukemia.

    The goal is to destroy cells that contain the BCR-ABL gene, which leads to too many abnormal white blood cells.

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    The First Steps

    Your doctor will decide on a treatment plan based on the stage of your disease. He'll likely start you off with a type of drug called a tyrosine kinase inhibitor (TKI). It blocks a protein called tyrosine kinase, which is made by the BCR-ABL gene and plays a role in the growth of abnormal blood cells.

    Your doctor will likely prescribe a TKI such as:

    • Bosutinib (Bosulif)
    • Dasatinib (Sprycel)
    • Imatinib (Gleevec)
    • Nilotinib (Tasigna)
    • Ponatinib (Iclusig)

    Most people get a quick response from these drugs. Your doctor will likely know in 3 to 6 months if your treatment works.

     

    You may go into "remission" while you take a TKI. That means that the abnormal gene is no longer in your cells. It doesn't mean that you're cured, but your CML is now under control.

    Always tell your doctor about any new symptoms. Some side effects that you might have from a TKI are:

    • Nausea and vomiting
    • Diarrhea
    • Rash
    • Headache
    • Fatigue
    • Lower blood cell counts

    Is Your Treatment Working?

    Your doctor will set several goals to help him check if your treatment is doing its job. For instance, he'll look to see that you have:

    • Normal blood cell counts with no signs of abnormal white blood cells, called a complete hematologic response.
    • No blood or bone marrow cells that contain the "Philadelphia" chromosome, which creates the BCR-ABL gene. This is called a complete cytogenetic response.
    • No sign of BCR-ABL in your blood, also called a complete molecular response.

    Regular Testing

    While you take TKIs, you'll get regular blood tests, including:

    • Complete blood counts to check white blood cells, red blood cells, and platelets
    • Blood cell exams to check the percentage of abnormal blood cells
    • Cytogenetic analysis, which looks for the abnormal Philadelphia chromosome
    • Polymerase chain reaction (PCR) tests to check for the BCR-ABL gene

    A typical schedule for testing may look something like this:

    • During the first 3 months, you'll likely have a complete round of blood tests every 2 weeks.
    • At 3 months, you may get a follow-up bone marrow study. After the third month, you'll have blood and bone marrow tests at least once every 6 months until you have a complete cytogenetic response.
    • Once you have a complete cytogenetic and molecular response, you'll get a PCR test every 3-6 months and a cytogenetic analysis once every year.

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