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    Ewing Sarcoma

    Important
    It is possible that the main title of the report Ewing Sarcoma is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • EFT
    • Ewing family of tumors
    • Ewing tumor
    • Ewing's Sarcoma
    • TEF
    • tumor of the Ewing family (TEF)

    Disorder Subdivisions

    • Askin's tumor
    • Ewing sarcoma of bone
    • extraosseous Ewing (EOE) sarcoma
    • primitive neuroectodermal tumor (PNET)

    General Discussion

    Ewing sarcoma is a rare bone tumor that occurs most often in adolescents. It can also arise outside of the bone in soft tissue (extraosseous Ewing sarcoma). Ewing sarcoma is related to another type of tumor known as primitive neuroectodermal tumor (PNET). Researchers have learned that these tumors are associated with the same chromosomal abnormality (balanced reciprocal translocation) and share many physiological characteristics. Consequently, these tumors are sometimes collectively classified as the Ewing family of tumors (EFT). This general term encompasses Ewing sarcoma of bone, extraosseous Ewing sarcoma, primitive neuroectodermal tumor, and Askin's tumor (a tumor of the chest wall). Ewing sarcoma of bone accounts for approximately 70 percent of the tumors in this family. Generally, the term Ewing sarcoma is preferred because, despite the different names, it is one tumor, molecularly. Ewing sarcoma of bone most often affects the long bone of the legs (femur) and flat bones such as those found in the pelvis and chest well. Ewing sarcoma is an aggressive cancer that may spread (metastasize) to the lungs, other bones, and bone marrow potentially causing life-threatening complications. The exact cause of these tumors is unknown.

    Ewing sarcoma was first described in the medical literature in 1921 by Dr. James Ewing. Ewing sarcoma is the second most common primary bone tumor in children and accounts for approximately 2% of all childhood cancer diagnoses.

    NORD's report on Ewing sarcoma is a detailed summary of the main aspects of this rare disorder. The National Cancer Institute offers comprehensive, in-depth information on this disorder, which is available at,

    For patients: http://www.cancer.gov/cancertopics/pdq/treatment/ewings/Patient

    For healthcare professionals: http://www.cancer.gov/cancertopics/pdq/treatment/ewings/HealthProfessional

    Resources

    American Cancer Society, Inc.
    250 Williams NW St
    Ste 6000
    Atlanta, GA 30303
    USA
    Tel: (404)320-3333
    Tel: (800)227-2345
    TDD: (866)228-4327
    Internet: http://www.cancer.org

    National Cancer Institute
    6116 Executive Blvd Suite 300
    Bethesda, MD 20892-8322
    USA
    Tel: (301)435-3848
    Tel: (800)422-6237
    TDD: (800)332-8615
    Email: cancergovstaff@mail.nih.gov
    Internet: http://www.cancer.gov

    National Coalition for Cancer Survivorship
    1010 Wayne Avenue
    7th Floor
    Silver Spring, MD 20910
    Tel: (301)650-9127
    Fax: (301)565-9670
    Tel: (888)650-9127
    Email: info@canceradvocacy.org
    Internet: http://www.canceradvocacy.org/

    OncoLink: The University of Pennsylvania Cancer Center Resource
    3400 Spruce Street
    2 Donner
    Philadelphia, PA 19104-4283
    USA
    Tel: (215)349-8895
    Fax: (215)349-5445
    Email: hampshire@uphs.upenn.edu
    Internet: http://www.oncolink.upenn.edu

    Sarcoma Foundation of America
    9899 Main Street Ste 204
    Damascus, MD 20872
    USA
    Tel: (301)253-8687
    Fax: (301)253-8690
    Email: info@curesarcoma.org
    Internet: http://www.curesarcoma.org

    Sarcoma Alliance
    775 E. Blithedale #334
    Mill Valley, CA 94941
    USA
    Tel: (415)381-7236
    Fax: (415)381-7235
    Email: info@sarcomaalliance.org
    Internet: http://www.sarcomaalliance.org

    Rare Cancer Alliance
    1649 North Pacana Way
    Green Valley, AZ 85614
    USA
    Internet: http://www.rare-cancer.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Friends of Cancer Research
    1800 M Street NW
    Suite 1050 South
    Washington, DC 22202
    Tel: (202)944-6700
    Email: info@focr.org
    Internet: http://www.focr.org

    Cancer.Net
    American Society of Clinical Oncology
    2318 Mill Road Suite 800
    Alexandria, VA 22314
    Tel: (571)483-1780
    Fax: (571)366-9537
    Tel: (888)651-3038
    Email: contactus@cancer.net
    Internet: http://www.cancer.net/

    BeatSarcoma
    76 Ellsworth Street
    San Francisco, CA 94110
    Tel: (415)826-0474
    Email: info@beatsarcoma.org
    Internet: http://www.beatsarcoma.org/

    Northwest Sarcoma Foundation
    P.O. Box 91460
    Portland, OR 97291
    Tel: (503)954-5740
    Email: melissa@nwsarcoma.org
    Internet: http://www.nwsarcoma.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 1/14/2013
    Copyright 1990, 1995, 1997, 1998, 2005, 2013 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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