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    Cutaneous T-Cell Lymphomas

    Important
    It is possible that the main title of the report Cutaneous T-Cell Lymphomas is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    Disorder Subdivisions

    • Mycosis Fungoides
    • Sezary Syndrome
    • Granulomatous Slack Skin
    • Primary Cutaneous Anaplastic Large Cell Lymphomas
    • Lymphomatoid Papulosis
    • Subcutaneous Panniculitic T-Cell Lymphoma
    • Pagetoid Reticulosis (Woringer-Kolopp Disease)

    General Discussion

    Cutaneous T-cell lymphomas (CTCLs) are a group of disorders characterized by abnormal accumulation of malignant T-cells in the skin potentially resulting in the development of rashes, plaques and tumors. CTCLs belong to a larger group of disorders known as non-Hodgkin's lymphomas (NHLs), which are related malignancies (cancers) that affect the lymphatic system (lymphomas). Functioning as part of the immune system, the lymphatic system helps to protect the body against infection and disease. It consists of a network of tubular channels (lymph vessels) that drain a thin watery fluid known as lymph from different areas of the body into the bloodstream. Lymph accumulates in the tiny spaces between tissue cells and contains proteins, fats, and certain white blood cells known as lymphocytes.

    There are two main types of lymphocytes: B-lymphocytes, which may produce specific antibodies to "neutralize" certain invading microorganisms, and T-lymphocytes, which may directly destroy microorganisms or assist in the activities of other lymphocytes. CTCLs result from errors in the production of T-lymphocytes or transformation of T-lymphocytes into malignant cells. In CTCLs abnormal, uncontrolled growth and multiplication (proliferation) of malignant T-lymphocytes result in accumulation of these lymphocytes in the skin. In some cases, malignant lymphocytes may spread to affect the lymph nodes and eventually to other bodily tissues and organs, potentially resulting in life-threatening complications. The specific symptoms and physical findings may vary from case to case, depending upon the extent and region(s) of involvement, the specific type of CTCL present, and various additional factors.

    Non-Hodgkin's lymphomas, such as CTCLs, may also be categorized based upon certain characteristics of the cancer cells as seen under a microscope and how quickly they may tend to grow and spread. For example, CTCLs may be characterized as "low-grade" (or indolent) lymphomas, which tend to grow slowly and result in few associated symptoms, or "intermediate-grade" or "high-grade" (aggressive) lymphomas, which typically grow rapidly, requiring prompt treatment. Most cases of CTCL, especially the classic form (mycosis fungoides), are slow-growing (indolent) lymphomas.

    Resources

    Leukemia & Lymphoma Society
    1311 Mamaroneck Avenue
    Suite 310
    White Plains, NY 10605
    Tel: (914)949-5213
    Fax: (914)949-6691
    Tel: (800)955-4572
    Email: infocenter@LLS.org
    Internet: http://www.LLS.org

    American Cancer Society, Inc.
    250 Williams NW St
    Ste 6000
    Atlanta, GA 30303
    USA
    Tel: (404)320-3333
    Tel: (800)227-2345
    TDD: (866)228-4327
    Internet: http://www.cancer.org

    National Cancer Institute Physician Data Query
    Office of Communications and Education
    Public Inquiries Office
    6116 Executive Blvd
    Suite 300
    Bethesda, MD 20892-8322
    Tel: (800)422-6237
    Email: cancergovstaff@mail.nih.gov
    Internet: http://www.cancer.gov/cancertopics/pdq/cancerdatabase

    National Cancer Institute
    6116 Executive Blvd Suite 300
    Bethesda, MD 20892-8322
    USA
    Tel: (301)435-3848
    Tel: (800)422-6237
    TDD: (800)332-8615
    Email: cancergovstaff@mail.nih.gov
    Internet: http://www.cancer.gov

    National Coalition for Cancer Survivorship
    1010 Wayne Avenue
    7th Floor
    Silver Spring, MD 20910
    Tel: (301)650-9127
    Fax: (301)565-9670
    Tel: (888)650-9127
    Email: info@canceradvocacy.org
    Internet: http://www.canceradvocacy.org/

    Cancer Hope Network
    2 North Road
    Suite A
    Chester, NJ 07930
    Tel: (908)879-4039
    Fax: (908)879-6518
    Tel: (800)552-4366
    Email: info@cancerhopenetwork.org
    Internet: http://www.cancerhopenetwork.org

    OncoLink: The University of Pennsylvania Cancer Center Resource
    3400 Spruce Street
    2 Donner
    Philadelphia, PA 19104-4283
    USA
    Tel: (215)349-8895
    Fax: (215)349-5445
    Email: hampshire@uphs.upenn.edu
    Internet: http://www.oncolink.upenn.edu

    Lymphoma Research Foundation
    115 Broadway
    Suite 1301
    New York, NY 10006
    USA
    Tel: (212)349-2910
    Fax: (212)349-2886
    Tel: (800)235-6848
    Email: LRF@lymphoma.org
    Internet: http://www.lymphoma.org

    Canadian Cancer Society
    55 St. Clair Avenue West Suite 500
    Toronto, M4V 2Y7
    Canada
    Tel: 4164885400
    Fax: 4164882872
    Tel: 8002688874
    Email: webmaster@ontario.cancer.ca
    Internet: http://www.cancer.ca/

    Lymphoma Foundation Canada
    16-1375 Southdown Road
    Suite 236
    Mississauga
    Ontario, L5J 2Z1
    Canada
    Tel: 9058225135
    Fax: 9058149152
    Tel: 8666595556
    Email: info@lymphoma.ca
    Internet: http://www.lymphoma.ca

    Lymphoma Association (UK)
    PO Box 386
    Aylesbury, HP20 2GA
    United Kingdom
    Tel: 01296619400
    Email: information@lymphomas.org.uk
    Internet: www.lymphomas.org.uk

    International Cancer Alliance for Research and Education (ICARE)
    4853 Cordell Avenue
    Suite 14
    Bethesda, MD 20814
    Tel: (301)656-3461
    Fax: (301)654-8684
    Tel: (800)422-7361
    Email: info@icare.org
    Internet: http://www.icare.org

    Rare Cancer Alliance
    1649 North Pacana Way
    Green Valley, AZ 85614
    USA
    Internet: http://www.rare-cancer.org

    Cutaneous Lymphoma Foundation
    PO Box 374
    Birmingham, MI 48012-0374
    USA
    Tel: (248)644-9014
    Fax: (248)233-3769
    Email: info@clfoundation.org
    Internet: http://www.clfoundation.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Friends of Cancer Research
    1800 M Street NW
    Suite 1050 South
    Washington, DC 22202
    Tel: (202)944-6700
    Email: info@focr.org
    Internet: http://www.focr.org

    Cancer Support Community
    1050 17th St NW Suite 500
    Washington, DC 20036
    Tel: (202)659-9709
    Fax: (202)974-7999
    Tel: (888)793-9355
    Internet: http://www.cancersupportcommunity.org/

    Lance Armstrong Foundation
    2201 E. Sixth Street
    Austin, TX 78702
    Tel: (512)236-8820
    Fax: (512)236-8482
    Tel: (877)236-8820
    Email: media@livestrong.org
    Internet: http://www.livestrong.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 1/3/2007
    Copyright 1989, 1996, 1997, 1998, 2002, 2003, 2007 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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