Childhood Non-Hodgkin Lymphoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - High-Stage Childhood Anaplastic Large Cell Lymphoma Treatment
Children and adolescents with high-stage (stage III or IV) anaplastic large cell lymphoma have a disease-free survival of approximately 60% to 75%.[1,2,3,4,5,6] It is unclear which strategy is best for the treatment of high-stage anaplastic large cell lymphoma. The German Berlin-Frankfurt-Munster (BFM) group used six cycles of intensive pulsed therapy, similar to their B-cell non-Hodgkin lymphoma (NHL) therapy (GER-GPOH-NHL-BFM-90 [NHL-BFM-90]).; [Level of evidence: 1iiA] Building on these results, the European Intergroup for Childhood NHL (EICNHL) group conducted the FRE-IGR-ALCL99 study (based on the GER-GPOH-NHL-BFM-90 regimen). First, this randomized study demonstrated that methotrexate 1 g/m2 infused over 24 hours plus intrathecal methotrexate and methotrexate 3 g/m2 infused over 3 hours without intrathecal methotrexate yielded similar outcomes.[Level of evidence: 1iiC] However, methotrexate 3 g/m2 over 3 hours had less toxicity than methotrexate 1 g/m2 over 24
Adult Non-Hodgkin Lymphoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Treatment for Diffuse, Small Noncleaved-Cell / Burkitt Lymphoma
Diffuse, small, noncleaved-cell/Burkitt lymphoma typically involves younger patients and represents the most common type of pediatric NHL.Standard Treatment Options for Diffuse, Small Noncleaved-Cell/Burkitt LymphomaStandard treatment options for diffuse, small, noncleaved-cell/Burkitt lymphoma include the following:Aggressive multidrug regimens.Central nervous system (CNS) prophylaxis.Aggressive multidrug regimensStandard treatment for diffuse, small, noncleaved-cell/Burkitt lymphoma is usually with aggressive multidrug regimens similar to those used for the advanced-stage aggressive lymphomas (such as diffuse large cell).[2,3,4] In some institutions, treatment includes the use of consolidative bone marrow transplantation.[5,6] Adverse prognostic factors include bulky abdominal disease and high serum lactate dehydrogenase.Evidence (aggressive multidrug regimens):An intensive clinical trial (CLB-9251 [NCT00002494]) used aggressive combination chemotherapy patterned after that used
Acute Lymphoblastic Leukemia
WebMD explains acute lymphoblastic leukemia (ALL), including its symptoms, risk factors, and treatments.
WebMD explains Burkitt lymphoma, including its symptoms, causes, and treatments.
Acute Myeloid Leukemia
WebMD explains acute myeloid leukemia (AML), a type of blood cancer, including symptoms, risk factors, and treatments.
WebMD explains multiple myeloma, a blood disorder, including its risk factors, symptoms, diagnosis, and treatments.
Understanding Leukemia -- Symptoms
Information on the symptoms of leukemia.
Understanding Leukemia -- the Basics
Get the basics about leukemia from the experts at WebMD.
Understanding Leukemia -- Diagnosis and Treatment
A look at the treatment of leukemia from the experts at WebMD.
Understanding Non-Hodgkin Lymphoma -- Symptoms
Information on the symptoms of non-Hodgkin lymphoma.