human blood cells close up
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What Are They?

Your blood is a mix of fluid and different kinds of cells and proteins. Red blood cells carry oxygen, and white blood cells fight disease. Tiny cell fragments called platelets help your blood clot to patch up a cut. Some types of cancer affect the parts of your body that make these things, including leukemia, lymphomas, and myelomas. More than 171,000 people were expected to be diagnosed with blood cancers in 2016.

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three generations of family
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Who’s More Likely to Get Them?

Doctors don’t know what causes them, but some things can raise your chances of getting one. These include having a family member who’s had one, being around certain chemicals (like benzene, found in gasoline and other fuels), or being exposed to high levels of radiation. In some cases, people who are HIV-positive or have AIDS, or have had the Epstein-Barr virus, may be more likely to get certain types of blood cancer.

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lymphatic system illustration
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Lymphoma

Your body has a network called the lymphatic system, which helps you fight off infection. It includes organs all over your body called lymph nodes -- that filter out bacteria and viruses -- and white blood cells called lymphocytes. Cancers that attack the lymphatic system are known as lymphomas.They’re the most common kind of blood cancer. Because your lymphatic system runs throughout your body, this type can start almost anywhere.

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clumping lymphoma cells
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Types of Lymphoma

There are two kinds -- Hodgkin's and non-Hodgkin's -- and they both happen in a similar way. Your body makes lymphocytes that don’t work the way they should, and they clump together to form tumors. They can crowd out healthy white blood cells so they can’t help you fight off disease.

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hodgkins lymphoma cells
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Hodgkin's Lymphoma

The difference between the two types of lymphoma is in the lymphocyte that’s involved. With Hodgkin's lymphoma, your body makes a kind called Reed-Sternberg cells. About 12% of people who have lymphoma have this type, which is named for the doctor who identified it in 1832. It’s one of the most curable forms of cancer.

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non hodgkins lymphoma cells
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Non-Hodgkin's Lymphoma

If it doesn’t involve Reed-Sternberg cells, it’s called non-Hodgkin's lymphoma. This is the most common form of lymphoma -- more than 30 types of cancer fall into this category. Some kinds grow slowly, while others grow very fast and can spread to other parts of your body. These need to be treated right away and can be hard to cure.

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lymph node biopsy
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Lymphoma Symptoms and Diagnosis

The most common signs are swollen lymph nodes, fever, unexplained weight loss, and feeling tired. You also might:

  • Sweat at night
  • Cough
  • Have pain in your chest or belly
  • Not feel hungry
  • Have an enlarged spleen or liver

If your doctor thinks you have lymphoma, she’ll probably want to take a small sample of one of your lymph nodes. From the sample, she'll be able to tell if you have cancer and, if so, what kind.

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leukemia cells
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Leukemia

This type of cancer affects your blood and bone marrow -- spongy tissue inside your bones where blood cells are made. Like lymphoma, it causes your body to make many white blood cells that don’t work right and keep healthy ones from fighting infection. But leukemia also keeps your bone marrow from making red blood cells and platelets the way it should. It’s the most common type of cancer in children, but adults can get it, too.

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mature man feeling feverish
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Leukemia Symptoms

This type of blood cancer can make you feel like you have the flu. You might have a fever, feel weak or sweaty, and have aches in your joints. You also might have:

  • Swollen lymph nodes
  • Unexplained weight loss
  • Bleeding or swollen gums

Other symptoms can include getting infections often, bruising easily, and anemia, which is when your body doesn’t make enough red blood cells.

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blood draw close up
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Leukemia Diagnosis

Your doctor can test your blood and see if you have more white blood cells than normal or low numbers of red blood cells or platelets -- both can be signs of leukemia. She also might want to take a sample of your bone marrow (called a biopsy) to look for cancer cells. She’ll give you medicine to numb the area, then put a needle into a large bone to take out a small amount to have tested.

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myeloma cells in bone marrow
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Myeloma

This type of blood cancer affects white blood cells called plasma cells. They make proteins called antibodies that attack bacteria and viruses in your body. If you have myeloma, your body turns out lots of problem plasma cells that make a protein that doesn’t help fight infections. These proteins can build up in your bone marrow and damage your kidneys, or in your bones and make them weak.

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man rubbing numb hands close up
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Myeloma Symptoms and Diagnosis

You may not notice symptoms early on, but the first sign is typically bone pain, usually in your back or ribs. You also may feel weak, get infections often, be very thirsty and need to pee more, be constipated, or have numb hands or feet. If your doctor thinks you might have myeloma, you’ll have blood tests to check for high levels of certain proteins, a bone marrow biopsy to look for cancer cells, and scans to see if your bones are thin or fractured.

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Treatment: Radiation and Chemotherapy

Blood cancer treatments usually involve chemotherapy or radiation -- or a combination of the two -- to kill the cancer cells. Chemotherapy uses powerful drugs to target the cells, while radiation uses high-energy rays to attack them. These can also damage healthy cells, cause side effects like nausea and hair loss, and make you more likely to get an infection. 

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Treatment: Stem Cell Transplant

If other treatments don't work or your doctor thinks your cancer may come back, she might recommend this. Stem cells can become different types of cells, so the idea is to replace problem stem cells with ones that will become healthy blood or immune cells. You’ll have chemotherapy or radiation to kill problem cells, then you’ll get donated stem cells. It works like a blood transfusion -- the cells go through a tube into a large blood vessel.

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researcher working with blood samples
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Look Ahead

Research is under way to boost your chances of beating all kinds of blood cancer. Talk with your doctor about clinical trials that might be right for you. These trials test new drugs to see if they’re safe and if they work. They often are a way to try new medicine that isn't available to everyone.

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Sources | Medically Reviewed on 03/12/2017 Reviewed by Laura J. Martin, MD on March 12, 2017

IMAGES PROVIDED BY:

1) Sebastian Kaulitzki / Thinkstock

2) Soul / Thinkstock

3) SomkiatFakmee / Thinkstock

4) Steve Gschmeissner / Science Source

5) Dr. E. Walker / Science Source

6) CNRI / Science Source

7) BSIP / A. BENOIST / Medical Images

8) Southern Illinois University / Science Source

9) Jupiterimages / Thinkstock

10) anna1311 / THINKSTOCK

11) Biophoto Associates / Science Source

12) nebari / Thinkstock

13) Michael Anderson / National Cancer Institute / Wikimedia Commons

14) Fnaq / Wikimedia Commons

15) kasto80 / Thinkstock

 

SOURCES:

National Cancer Institute.

American Society of Hematology: “Blood Cancers.”

The Leukemia and Lymphoma Society.

CDC: “Questions and Answers about Leukemia.”

Genes and Disease, National Center for Biotechnology Information, Bethesda, MD, 1998.

Dean, L. Blood Groups and Red Cell Antigens, National Center for Biotechnology Information, Bethesda, MD, 2005.

Johns Hopkins Medicine, Sidney Kimmel Comprehensive Cancer Center.

Reviewed by Laura J. Martin, MD on March 12, 2017

This tool does not provide medical advice. See additional information.

THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.