Adult Acute Lymphoblastic Leukemia Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Treatment Option Overview
Successful treatment of ALL consists of the control of bone marrow and systemic disease and the treatment (or prevention) of sanctuary-site disease, particularly the central nervous system (CNS).[1,2] The cornerstone of this strategy includes systemically administered combination chemotherapy with CNS preventive therapy. CNS prophylaxis is achieved with chemotherapy (intrathecal and/or high-dose systemic therapy) and, in some cases, cranial radiation therapy. Treatment is divided into the following three phases:Remission induction.CNS prophylaxis.Postremission (also called remission continuation or maintenance).The average length of treatment for ALL varies between 1.5 and 3 years in the effort to eradicate the leukemic cell population. Younger adults with ALL may be eligible for selected clinical trials for childhood ALL. (Refer to the PDQ summary on Childhood Acute Lymphoblastic Leukemia Treatment for more information.) Entry into a clinical trial is highly desirable to assure
Changes to This Summary (05 / 29 / 2013)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Editorial changes were made to this summary.This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.
Spirituality in Cancer Care (PDQ®): Supportive care - Health Professional Information [NCI] - Current Clinical Trials
Check NCI's list of cancer clinical trials for U.S. supportive and palliative care trials about spiritual concerns and spiritual therapy that are now accepting participants. The list of trials can be further narrowed by location, drug, intervention, and other criteria. General information about clinical trials is also available from the NCI Web site.
Male Breast Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - General Information About Male Breast Cancer
Incidence and Mortality Estimated new cases and deaths from breast cancer (men only) in the United States in 2011:[ 1 ] New cases: 2,140. Deaths: 450. Male breast cancer is rare.[ 2 ] Less than 1% of all breast carcinomas occur in men.[ 3,4 ] The mean age at diagnosis is between 60 and 70 years,though men of all ages can be affected with the disease. Predisposing risk factors [ 5 ] appear ...
Newcastle Disease Virus (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Summary of the Evidence for Newcastle Disease Virus
In view of the evidence accumulated to date, no conclusions can be drawn about the effectiveness of using Newcastle disease virus in the treatment of cancer. Most reported clinical studies have involved few patients, and historical control subjects rather than actual control groups have often been used for outcome comparisons. Poor descriptions of study design and incomplete reporting of clinical data have hindered evaluation of many of the reported findings. However, while most studies are small and lack adequate controls, the number of studies suggesting a potential clinical value warrants further attention.Separate levels of evidence scores are assigned to qualifying human studies on the basis of statistical strength of the study design and scientific strength of the treatment outcomes (i.e., endpoints) measured. The resulting two scores are then combined to produce an overall score. For additional information about levels of evidence analysis, refer to Levels of Evidence for Human
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Call 1-800-4-CANCERFor more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 8:00 a.m. to 8:00 p.m., Eastern Time. A trained Cancer Information Specialist is available to answer your questions.Chat online The NCI's LiveHelp® online chat service provides Internet users with the ability to chat online with an Information Specialist. The service is available from 8:00 a.m. to 11:00 p.m. Eastern time, Monday through Friday. Information Specialists can help Internet users find information on NCI Web sites and answer questions about cancer. Write to usFor more information from the NCI, please write to this address:NCI Public Inquiries Office9609 Medical Center Dr. Room 2E532 MSC 9760Bethesda, MD 20892-9760Search the NCI Web siteThe NCI Web site provides online access to information on cancer, clinical trials, and other Web sites and organizations that offer support
Colorectal Cancer Prevention (PDQ®): Prevention - Health Professional Information [NCI] - Who is at Risk?
For the great majority of people,the major factor that increases a person's risk for colorectal cancer (CRC) is increasing age. Risk increases dramatically after age 50 years; 90% of all CRCs are diagnosed after this age. The history of CRC in a first-degree relative,especially if before the age of 55 years,roughly doubles the risk. Other risk factors are weaker than age and family history. ...
Spirituality in Cancer Care (PDQ®): Supportive care - Health Professional Information [NCI] - Screening and Assessment of Spiritual Concerns
Raising spiritual concerns with patients can be accomplished by the following approaches:[1,2]Waiting for the patient to bring up spiritual concerns.Requesting that the patient complete a paper-and-pencil assessment.Having the physician do a spiritual inquiry or assessment by indicating his or her openness to a discussion.These approaches have different potential value and limitations. Patients may express reluctance to bring up spiritual issues, noting that they would prefer to wait for the provider to broach the subject. Standardized assessment tools vary, have generally been designed for research purposes, and need to be reviewed and utilized appropriately by the provider. Physicians, unless trained specifically to address such issues, may feel uncomfortable raising spiritual concerns with patients. However, an increasing number of models are becoming available for physician use and training.Numerous assessment tools are pertinent to performing a religious and
Topics in Complementary and Alternative Therapies (PDQ®): Complementary and alternative medicine - Patient Information [NCI] - Acupuncture
Acupuncture is a part of traditional Chinese medicine used in China and other Asian countries for thousands of years. In patients with cancer, acupuncture is usually used to relieve symptoms, treat side effects of therapy, and improve quality of life. It may help the immune system work better, control nausea and vomiting caused by chemotherapy, and relieve cancer pain. Acupuncture may treat weight loss, anxiety, depression, insomnia, poor appetite, and gastrointestinal symptoms (constipation and diarrhea). See the PDQ patient summary on Acupuncture for more information.
Genetics of Endocrine and Neuroendocrine Neoplasias (PDQ®): Genetics - Health Professional Information [NCI] - About This PDQ Summary
Purpose of This SummaryThis PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the genetics of endocrine and neuroendocrine neoplasias. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.Reviewers and UpdatesThis summary is reviewed regularly and updated as necessary by the PDQ Cancer Genetics Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH). Board members review recently published articles each month to determine whether an article should:be discussed at a meeting,be cited with text, orreplace or update an existing article that is already cited.Changes to the summaries are made through a