Childhood Non-Hodgkin Lymphoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - High-Stage Childhood Anaplastic Large Cell Lymphoma Treatment
Children and adolescents with high-stage (stage III or IV) anaplastic large cell lymphoma have a disease-free survival of approximately 60% to 75%.[1,2,3,4,5,6] It is unclear which strategy is best for the treatment of high-stage anaplastic large cell lymphoma. The German Berlin-Frankfurt-Munster (BFM) group used six cycles of intensive pulsed therapy, similar to their B-cell non-Hodgkin lymphoma (NHL) therapy (GER-GPOH-NHL-BFM-90 [NHL-BFM-90]).; [Level of evidence: 1iiA] Building on these results, the European Intergroup for Childhood NHL (EICNHL) group conducted the FRE-IGR-ALCL99 study (based on the GER-GPOH-NHL-BFM-90 regimen). First, this randomized study demonstrated that methotrexate 1 g/m2 infused over 24 hours plus intrathecal methotrexate and methotrexate 3 g/m2 infused over 3 hours without intrathecal methotrexate yielded similar outcomes.[Level of evidence: 1iiC] However, methotrexate 3 g/m2 over 3 hours had less toxicity than methotrexate 1 g/m2 over 24
Esophageal Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular Classification of Esophageal Cancer
Fewer than 50% of esophageal cancers are squamous cell carcinomas. Adenocarcinomas,typically arising in Barrett esophagus,account for at least 50% of malignant lesions,and the incidence of this histology appears to be rising. Barrett esophagus contains glandular epithelium cephalad to the esophagogastric junction. Three different types of glandular epithelium can be seen: Metaplastic ...
Intraocular (Uveal) Melanoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Ciliary Body Melanoma
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.) Melanoma involving the ciliary body is a rare tumor that carries a poor ...
Pruritus (PDQ®): Supportive care - Patient Information [NCI] - Overview
Pruritus is an itching sensation that triggers the desire to scratch. It is a distressing symptom that can cause discomfort. Scratching may cause breaks in the skin that may result in infection. Pruritus can be related to anything from dry skin to undiagnosed cancer. It can occur in people who have cancer or in those who have received cancer treatment. ...
Hypercalcemia (PDQ®): Supportive care - Patient Information [NCI] - Current Clinical Trials
Check NCI's list of cancer clinical trials for U.S. supportive and palliative care trials about hypercalcemia of malignancy that are now accepting participants. The list of trials can be further narrowed by location,drug,intervention,and other criteria. General information about clinical trials is also available from the NCI Web site. ...
Malignant Melanoma is a common skin cancer that arises from the melanin cells within the upper layer of the skin (epidermis) or from similar cells that may be found in moles (nevi). This type of skin cancer may send down roots into deeper layers of the skin. Some of these microscopic roots may spread (metastasize) causing new tumor growths in vital organs of the body.. ...
Gallbladder Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Get More Information From NCI
This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information on gallbladder cancer treatment.
Adult Acute Lymphoblastic Leukemia Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular Classification of Adult ALL
The following leukemic cell characteristics are important: Morphological features. Cytogenetic characteristics. Immunologic cell surface and biochemical markers. Cytochemistry. In adults,French-American-British (FAB) L1 morphology (more mature-appearing lymphoblasts) is present in fewer than 50% of patients,and L2 morphology (more immature and pleomorphic) predominates.[ 1 ] L3 (Burkitt) ...
Cartilage (Bovine and Shark) (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - History
The therapeutic potential of cartilage has been investigated for more than 30 years. As noted previously (General Information),cartilage products have been tested as treatments for cancer,psoriasis,and arthritis. Cartilage products have also been studied as enhancers of wound repair and as treatments for osteoporosis,ulcerative colitis,regional enteritis,acne,scleroderma,hemorrhoids,...
Nasopharyngeal Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - nci_ncicdr0000062966-nci-header
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Nasopharyngeal Cancer Treatment