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    Multiple Endocrine Neoplasia Type 2

    Important
    It is possible that the main title of the report Multiple Endocrine Neoplasia Type 2 is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • MEN-2
    • MEN-2 syndrome

    Disorder Subdivisions

    • familial medullary thyroid carcinoma (FMTC)
    • MEN 2A (Sipple syndrome)
    • MEN 2B (multiple neuroma syndrome)
    • multiple endocrine neoplasia type 2A
    • multiple endocrine neoplasia type 2B
    • Wagenmann-Froboese syndrome

    General Discussion

    Multiple endocrine neoplasia (MEN) type 2 is a rare genetic disorder characterized by an increased risk of developing a specific form of thyroid cancer (medullary thyroid carcinoma) and benign tumors affecting additional glands of the endocrine system. The endocrine system is the network of glands that secrete hormones into the bloodstream where they travel to various areas of the body. These hormones regulate the chemical processes (metabolism) that influence the function of various organs and activities within the body. Hormones are involved in numerous vital processes including regulating heart rate, body temperature and blood pressure. Glands affected in MEN type 2 may secrete excessive amounts of hormones into the bloodstream, which can result in a variety of symptoms.

    MEN type 2 is divided into three subtypes: MEN type 2A, MEN type 2B, and familial medullary thyroid carcinoma (FMTC). Medullary thyroid carcinoma (MTC) affects nearly all individuals with MEN type 2 regardless of the subtype. Additional symptoms may occur depending upon the specific subtype present. In FMTC, no other symptoms besides the carcinoma are present. MEN type 2 can run in families or can occur as the result of a spontaneous genetic change (i.e., new mutation) that occurs randomly for no apparent reason.

    Resources

    American Cancer Society, Inc.
    250 Williams NW St
    Ste 6000
    Atlanta, GA 30303
    USA
    Tel: (404)320-3333
    Tel: (800)227-2345
    TDD: (866)228-4327
    Internet: http://www.cancer.org

    NIH/National Institute of Diabetes, Digestive & Kidney Diseases
    Office of Communications & Public Liaison
    Bldg 31, Rm 9A06
    31 Center Drive, MSC 2560
    Bethesda, MD 20892-2560
    Tel: (301)496-3583
    Email: NDDIC@info.niddk.nih.gov
    Internet: http://www2.niddk.nih.gov/

    Canadian Multiple Endocrine Neoplasia Society, Inc.
    1432 107th Street
    North Battleford, S9A 19
    Canada
    Tel: 3064458436
    Fax: 3064458436
    Email: hockey_freak99@hotmail.com

    Hormone Health Network
    8401 Connecticut Avenue
    Suite 900
    Chevy Chase, MD 20815-5817
    Fax: (310)941-0259
    Tel: (800)467-6663
    Email: hormone@endo-society.org
    Internet: http://www.hormone.org/

    ThyCa: Thyroid Cancer Survivors' Association, Inc.
    PO Box 1545
    New York, NY 10159-1545
    Fax: (630)604-6078
    Tel: (877)588-7904
    Email: thyca@thyca.org
    Internet: http://www.thyca.org

    Association for Multiple Endocrine Neoplasia Disorders (AMEND)
    The Warehouse
    No. 1 Draper Street
    Royal Tunbridge Wells
    Kent, TN4 0PG
    United Kingdom
    Tel: 00441892516076
    Fax: 00441892516076
    Email: jo.grey@amend.org.uk
    Internet: http://www.amend.org.uk

    NET Patient Foundation
    Boxtrees Farm
    The Farm House
    Stratford Road
    Hockley Heath, B94 6EA
    United Kingdom
    Tel: 08004346476
    Internet: http://www.netpatientfoundation.org

    American Multiple Endocrine Neoplasia Support
    1027 Hampshire Drive
    Maryville, TN 37801
    Tel: (865)238-5872
    Fax: (865)238-5844
    Tel: (866)612-8579
    Email: Linda@hagemanfoundation.org
    Internet: http://www.amensupport.org

    Pheo Para Troopers
    P.O. Box 2064
    Kokomo, IN 46904
    Email: info@pheoparatroopers.org
    Internet: http://www.pheoparatroopers.org

    Hageman Foundation
    1027 Hampshire Drive
    Maryville, TN 37801
    Tel: (865)238-5842
    Fax: (865)238-5844
    Tel: (866)612-8579
    Email: Info@HagemanFoundation.org
    Internet: http://www.HagemanFoundation.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 1/20/2011
    Copyright 2011 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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