The goal of multiple myeloma treatment is to shrink your tumors, stop the cancer from spreading, keep your bones strong, and help you feel better and live longer. To do this, you might get medication, a stem-cell transplant, radiation, a type of blood filtering called plasmapheresis, and surgery.
The treatment plan you and your doctor choose will depend on:
Which Drugs Treat Multiple Myeloma?
Chemotherapy drugs for multiple myeloma kill cancer cells or keep them from spreading. They include:
- Bendamustine (Treanda)
- Cyclophosphamide (Cytoxan)
- Doxorubicin (Adriamycin)
- Etoposide (VP-16)
- Liposomal doxorubicin (Doxil)
- Melphalan (Alkeran)
- Vincristine (Oncovin)
Your doctor may suggest that you take other drugs to fight your multiple myeloma along with your chemotherapy.
Some drugs help your immune system fight cancer cells in your blood. They include daratumumab (Darzalex), elotuzumab (Empliciti), lenalidomide (Revlimid), pomalidomide (Pomalyst), and thalidomide (Thalomid). These drugs may cause birth defects if you take them while you’re pregnant, so talk to your doctor about using birth control.
Multiple myeloma can make your bones weaker and more likely to break. Your doctor may give you drugs to help strengthen your bones, including pamidronate (Aredia) and zoledronic acid (Zometa). These drugs are called bisphosphonates.
Stem Cell Transplant
Myeloma damages your bone marrow where cells, called stem cells, make new blood. A stem cell transplant can help your body make new, healthy blood cells. You can get new stem cells from a healthy donor, or your doctor can collect some of your own from your blood and give them back to you. The latter is the standard treatment for multiple myeloma.
Before a transplant, you’ll get high-dose chemotherapy to kill any cancer in your bone marrow. It could last for several days. Then the doctor will put stem cells back into your blood through an IV. (If you’re using your own stem cells, the doctor will collect them from you before you start chemo.) You won’t feel any pain, and you’ll be awake while it’s happening.
It can take up to 2 weeks after the transplant for your bone marrow to start making new blood cells. You may need to stay in the hospital during this time. You’ll also have a higher risk of infection, so your doctor might give you antibiotics to keep you from getting sick.
Using your own stem cells for a transplant can make myeloma go away for a while, sometimes several years, but it won’t cure the disease.
Your doctor may try other treatments to fight your multiple myeloma.
- Radiation, along with drugs, can kill cancer cells or treat bones that the disease has damaged.
- You might have surgery to remove tumors or treat bones or muscles damaged by multiple myeloma.
- Plasmapheresis is a way to remove myeloma from the liquid part of your blood, called plasma. It won’t get rid of your disease, but it may relieve your symptoms for a short time. You’ll probably also get chemotherapy or treatment with another drug at the same time.
Will I Have Side Effects?
Side effects are possible, though not everyone has the same ones. The treatments may not affect you as much as another person. Some, like blood clots, may be serious but are rare.
The side effects you might have from multiple myeloma treatment include:
- Too few red blood cells (called anemia)
- Bleeding problems
- Blood clots
- Nerve pain, tingling, or numbness
Talk to your doctor about how your treatment makes you feel. There may be ways to reduce your side effects, including lowering your drug dosage, changing medications, taking aspirin to fight blood clots, changing your diet to help with constipation or diarrhea, or giving you other medicines to ease nausea or fatigue.
What Else Can I Do?
Stick with your multiple myeloma treatment plan. Your medications will work better against your cancer if you take them as prescribed. If you take pills at home, follow the instructions carefully.
Don’t be afraid to talk to your doctor or nurse if you don’t understand how to take your medicine. Don’t stop taking it if you have side effects. Instead, call your doctor’s office and talk about your options.