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New Blood Test Spots Cancer

Could Be Available as Early as 2004
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Dec. 13, 2002 (San Antonio, Texas) -- In what's being called one of the biggest advances in cancer research in years, scientists have developed a blood test that can detect cancer with a greater than 90% accuracy. This artificial intelligence -- already tested for cancers of the breast, ovary, and lung -- could one day be used to detect many types of cancer.

The government researcher leading the development of the computer-assisted technology is optimistic that a blood test for ovarian cancer could be available as early as 2004. And tests for prostate, breast, and lung cancers could soon follow, predicted Emanuel Petricoin III, PhD, co-director of the Clinical Proteomics Program, a joint program of the FDA and the National Cancer Institute.

The blood test could prove one of the biggest developments in cancer research in years, he says. The benefits of the test would be twofold. Not only would it offer a way to detect some cancers earlier, when they're still curable, the test would also allow some patients to avoid unnecessary biopsies and all the anxiety and risks that come with them.

But before it's ready for prime time, doctors meeting at the 25th Annual San Antonio Breast Cancer Symposium cautioned the test needs to be validated in large numbers of men and women in clinical trials.

The test involves scanning tiny amounts of blood for hidden patterns of proteins that distinguish cancerous tissue from benign, much like the bar codes on food and household products that reveal their price at the supermarket checkout.

"All that's needed [for the quick fingerstick test] is a single drop of blood," Petricoin says. "The computer does the rest."

The feasibility of the approach was first proved in ovarian cancer, an often-deadly form of cancer because there is currently no way to detect it early, in its curable stages.

In tests on several hundred blood samples, some taken from women with ovarian cancer and others from healthy women, the test proved "an astonishing" 100% accurate in detecting cancer, even at the earliest stages, Petricoin said.

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