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New Childhood Leukemia Drug Approved

30% of Kids Improve When Other Treatments Have Failed
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Side Effects

In addition to suppressing production of immune system cells in the bone marrow, Clolar can have other potentially serious side effects.

By killing leukemia cells in the bloodstream, Clolar can lead to the release of cell contents that could lead to a widespread inflammatory response in the body. Patients' breathing and blood pressure should be watched closely while Clolar is being given.

Clolar is given intravenously for one to two hours a day for five consecutive days. This is repeated for two to six cycles every 28 days depending on the response to treatment.

Heart problems, including a fast heart rate, fluid around the heart, and weakened heart pumping occurred in up to 35% of patients. However, Genzyme says it's unclear if Clolar actually caused the problems.

Other side effects from Clolar include:

  • Vomiting
  • Nausea
  • Diarrhea
  • Anemia
  • Fever from low white blood cell count (cells that fight infection)

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