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    Does Being Breastfed Affect Later Cancer Risk?

    Study Shows Little Evidence of a Link
    WebMD Health News
    Reviewed by Louise Chang, MD

    Oct. 4, 2005 - Being breastfed as an infant has little impact on cancer risk as an adult, according to a newly published study and a review of earlier research.

    Researchers from the England's University of Bristol found no evidence that being breastfed increases cancer risk. A slight protective benefit against breast cancer prior to menopause was found for women who were breastfed as infants. But Richard M, Martin, PhD, who led the research team, tells WebMD that the finding is far from conclusive.

    "These findings show that being breastfed doesn't increase cancer risk as an adult," he says. "There are still many unanswered questions, including whether breastfeeding is protective against heart disease and its role in brain development."

    Early Studies

    Animal studies from the 1930s and 1940s first led researchers to suggest that viruses transmitted in breast milk might cause cancer later in life. Although little evidence emerged to back the claim, as late as the 1970s new moms with a family history of breast cancer were often warned not to breastfeed their daughters.

    High levels of a hormone associated with growth have also been linked to breast, prostate, and colorectal cancers. Breastfeeding is believed to increase circulating levels of the hormone, known as insulin-like growth factor-I (IGF-1) levels.

    "Because breastfeeding is positively associated with height and IGF-1 and because both are, in turn, positively associated with breast, prostate, and colorectal cancers, we hypothesized that breastfeeding may be associated with an increase in the risk of these cancers," Martin and colleagues wrote.

    Since breastfeeding is known to help prevent specific gastrointestinal infections, the researchers also suggested that it might help protect against GI cancers caused by these infections.

    In an effort to clarify the role of early-life exposure to breast milk in later-life cancer risk, Martin and colleagues analyzed almost 65 years of data on about 4,000 people in Britain followed from the late 1930s. The study subjects were all younger than 20 at enrollment and were in their 60s, 70s, and 80s at follow-up.

    The researchers also included 10 other studies that examined infant feeding and later cancer risk published between 1966 and 2005. The findings were published in the Oct. 5 issue of the Journal of the National Cancer Institute.

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