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Novel Cancer Drugs Target Tumor Roots

Agents Show Promise for Advanced Kidney, Thyroid, Ovarian Cancers

Anti-Angiogenesis Drug Fights Ovarian Cancer

A third study looked at women with advanced ovarian cancer that had returned and was resistant to the traditional chemotherapy drugs used to treat it. All the women were given the experimental anti-angiogenesis drug VEGF-Trap.

Researcher William P. Tew, MD, an assistant attending physician in the department of medicine at Memorial Sloan-Kettering Cancer Center, tells WebMD that anti-angiogenesis drugs can be particularly helpful in ovarian cancer because it is highly dependent on blood vessel growth in order to spread.

Preliminary results in the first 162 women show that tumors shrank in 8% of them, and tumors stopped growing for at least one month in 85% of the women. Thirty weeks into the study, 4% of women still show no signs of tumor growth.

While that might not sound like much, Bajorin notes that there is no approved treatment option for these patients.

Additionally, the drug relieved excess fluid in the space between the tissues lining the abdomen and abdominal organs. This is a huge problem in advanced ovarian cancer, which occurs in nearly one-third of women.

“We’re looking at women who have failed all known therapies and provided a drug that is well tolerated and improves their quality of life,” he tells WebMD.

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