Warning Sign for Cancer Drugs
Drugs That Block Tumor Blood Vessels May Harm Normal Cells
VEGF Inside Cells continued...
None of this means cancer patients should avoid VEGF inhibitors.
"If I had an aggressive cancer, I would take these drugs -- even the new
ones," Iruela-Arispe says. "If my choice is dying from cancer in six
months or taking a risk of a side effect that may never happen, I will
certainly take the risk. These are great drugs, but we should continue the
search for better ones."
Francis says the message is not that VEGF inhibitors are bad, but that
doctors and patients should be aware of the risks.
"If you get into treatments targeting this VEGF pathway, it is going to
have to be very carefully done," he says.
Iruela-Arispe and colleagues report their findings in the Aug. 24 issue of
the journal Cell.