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Vaccine May Help Treat Advanced Melanoma

Study Shows Experimental Vaccine May Shrink Tumors in Patients With Late-Stage Melanoma

How the Vaccine Works continued...

The study is published in the New England Journal of Medicine.

"This is a first vaccine study in melanoma that really shows an effect. This is fascinating," says Arkadiusz Dudek, MD, PhD, associate professor of medicine at the University of Minnesota's Masonic Cancer Center in Minneapolis.

Dudek recently reviewed the clinical evidence behind vaccines for melanoma, but he was not involved in the current research.

But for several reasons, he says, "It's not a home run."

For one thing, he says, there's no way for doctors to predict which patients might have a response to the vaccine treatment.

And the vaccine can't be used in everyone. The inoculation only works in people with a certain type of protein signature on the surface of their cells, called an HLA type, though researchers said the vaccine could be tailored, in the future, to work with different HLA types.

Patients also have to be healthy enough to withstand the toxic effects of treatment, which can be significant.

But for patients who are battling advanced melanoma, which is one of the deadliest kinds of cancer, any options, even limited ones, are likely to be welcome news.

"Cancer patients want to do something to fight their cancer, but if you have stage II or stage III disease, the standard of care is observation," says Tim Turnham, PhD, executive director of the Melanoma Research Foundation in Washington, D.C. "That's really tough for patients."

Using Vaccines to Fight Cancer

For the study, researchers recruited 185 patients at 21 centers across the U.S.

To be eligible for the study, patients had to have metastatic melanoma, either stage IV or locally advanced stage III, and they had to be HLA-type A0201, a tissue type carried by about half of people in the U.S.

All patients received high-dose IL-2 therapy. IL-2 was approved by the FDA in 1998 for the treatment of metastatic melanoma.

About half of patients, 91, were randomly assigned to also receive the experimental gp100 vaccine. That vaccine uses a protein found on the surface of cancer cells to flag those cells so they can be destroyed by the immune system.

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