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Non-Hodgkin's Lymphoma

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Adult Non-Hodgkin Lymphoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Non-Hodgkin Lymphoma

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Indolent, Stage I and Contiguous Stage II Adult Non-Hodgkin Lymphoma

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Understanding Non-Hodgkin Lymphoma -- Diagnosis & Treatment

Non-Hodgkin lymphoma is diagnosed by a tissue biopsy. If there is an enlarged, painless lymph node, without of an infection, a biopsy will be needed.  To perform a lymph node biopsy a doctor will cut into the lymph node to remove a sample of tissue or remove the entire lymph node. If the biopsy shows non-Hodgkin lymphoma, further testing will be needed to determine the specific type  as well as to determine the stage of disease. Depending on your specific symptoms, the type of the lymphoma, its...

Read the Understanding Non-Hodgkin Lymphoma -- Diagnosis & Treatment article > >

Treatment of indolent, stage I and contiguous stage II adult non-Hodgkin lymphoma may include the following:

  • Radiation therapy directed at the area where cancer is found.
  • Watchful waiting.
  • Chemotherapy with radiation therapy.
  • Radiation therapy directed at the area where cancer is found and nearby lymph nodes.
  • Monoclonal antibody therapy with or without chemotherapy.
  • Treatments used for more advanced disease, in patients who can't be treated with radiation therapy.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with indolent, stage I adult non-Hodgkin lymphoma and indolent, contiguous stage II adult non-Hodgkin lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Aggressive, Stage I and Contiguous Stage II Adult Non-Hodgkin Lymphoma

Treatment of aggressive, stage I and contiguous stage II adult non-Hodgkin lymphoma may include the following:

  • Combination chemotherapy with or without radiation therapy to areas where cancer is found.
  • A clinical trial of monoclonal antibody therapy and combination chemotherapy with steroids. Radiation therapy may also be given.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with aggressive, stage I adult non-Hodgkin lymphoma and aggressive, contiguous stage II adult non-Hodgkin lymphoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Indolent, Noncontiguous Stage II/III/IV Adult Non-Hodgkin Lymphoma

Treatment of indolent, noncontiguous stage II /III /IV adult non-Hodgkin lymphoma may include the following:

  • Watchful waiting for patients who do not have symptoms.
  • Chemotherapy with or without steroids.
  • Combination chemotherapy with steroids.
  • Monoclonal antibody therapy with or without chemotherapy.
  • Radiolabeled monoclonal antibody therapy.
  • Radiation therapy directed at the area where cancer is found and nearby lymph nodes, for patients who have stage II and stage III disease.
  • A clinical trial of chemotherapy with or without total-body irradiation (radiation therapy to the entire body) or radiolabeled monoclonal antibody therapy, followed by autologous or allogeneic stem cell transplant.
  • A clinical trial of chemotherapy with or without vaccine therapy.
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