Completely resected stage I and abdominal stage II
Nonresected stage I/II and stage III with LDH <500 IU/L
Stage III with LDH 500–999 IU/L
Stage IV, B-ALL (>25% blasts), no CNS disease, and LDH <1,000 IU/L
Stage III, IV, B-cell ALL with LDH >1,000 IU/L
Any CNS disease
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