In asymptomatic patients with indolent forms of advanced NHL, treatment may be
deferred until the patient becomes symptomatic as the disease progresses. When
treatment is deferred, the clinical course of patients with indolent NHL
varies; frequent and careful observation is required so that effective
treatment can be initiated when the clinical course of the disease accelerates.
Some patients have a prolonged indolent course, but others have disease that
rapidly evolves into more aggressive types of NHL that require immediate
Aggressive lymphomas are increasingly seen in HIV-positive patients; treatment
of these patients requires special consideration. (Refer to the PDQ summary on
AIDS-Related Lymphoma Treatment for more information.)
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