Non-Hodgkin's Lymphoma

Indolent, Stage I and Contiguous Stage II Adult Non-Hodgkin’s Lymphoma

Treatment of indolent, stage I and contiguous stage II adult non-Hodgkin’s lymphoma may include the following:

• Radiation therapy directed at the area where cancer is found.
• Watchful waiting.
• Radiation therapy directed at the area where cancer is found and nearby lymph nodes.
• Chemotherapy with radiation therapy.

Aggressive, Stage I and Contiguous Stage II Adult Non-Hodgkin’s Lymphoma

Treatment of aggressive, stage I and contiguous stage II adult non-Hodgkin’s lymphoma may include the following:

• Combination chemotherapy with or without radiation therapy to areas where cancer is found.
• A clinical trial of monoclonal antibody therapy and combination chemotherapy with steroids. Radiation therapy may also be given.

Indolent, Noncontiguous Stage II/III/IV Adult Non-Hodgkin’s Lymphoma

Treatment of indolent, noncontiguous stage II/III/IV adult non-Hodgkin’s lymphoma may include the following:

• Watchful waiting for patients who do not have symptoms.
• Chemotherapy with or without steroids.
• Combination chemotherapy with steroids.
• Monoclonal antibody therapy with or without combination chemotherapy.
• Radiolabeled monoclonal antibody therapy.
• Radiation therapy directed at the area where cancer is found and nearby lymph nodes, for patients who have stage III disease.
• A clinical trial of chemotherapy with or without total-body irradiation (radiation therapy to the entire body) or radiolabeled monoclonal antibody therapy, followed by autologous or allogeneic stem cell transplant.
• A clinical trial of chemotherapy with or without vaccine therapy.

This summary section refers to specific treatments under study in clinical trials, but it may not mention every new treatment being studied. Information about ongoing clinical trials is available from the NCI Web site.

Aggressive, Noncontiguous Stage II/III/IV Adult Non-Hodgkin’s Lymphoma

Treatment of aggressive, noncontiguous stage II/III/IV adult non-Hodgkin’s lymphoma may include the following:

• Combination chemotherapy alone.
• Combination chemotherapy with radiation therapy or monoclonal antibody therapy.
• Combination chemotherapy with CNS prophylaxis.
• A clinical trial of autologous or allogeneic stem cell transplant for patients who are likely to relapse.

This summary section refers to specific treatments under study in clinical trials, but it may not mention every new treatment being studied. Information about ongoing clinical trials is available from the NCI Web site.

Adult Lymphoblastic Lymphoma

Treatment of adult lymphoblastic lymphoma may include the following:

• Combination chemotherapy and CNS prophylaxis.
• A clinical trial of autologous or allogeneic stem cell transplant.

This summary section refers to specific treatments under study in clinical trials, but it may not mention every new treatment being studied. Information about ongoing clinical trials is available from the NCI Web site.

Diffuse Small Noncleaved Cell/Burkitt Lymphoma

Treatment of adult diffuse small noncleaved cell/Burkitt lymphoma may include the following:

• Combination chemotherapy and CNS prophylaxis.
• A clinical trial of combination chemotherapy.
• A clinical trial of autologous or allogeneic stem cell transplant.

This summary section refers to specific treatments under study in clinical trials, but it may not mention every new treatment being studied. Information about ongoing clinical trials is available from the NCI Web site.