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Non-Hodgkin's Lymphoma

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Stages of Adult Non-Hodgkin Lymphoma

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    Stage IV

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    Stage IV adult non-Hodgkin lymphoma. Cancer is found throughout one or more organs that are not part of a lymphatic area (lymph nodes, tonsils, thymus, or spleen) (a); or in one organ that is not part of a lymphatic area and has spread to lymph nodes far away from that organ (b); or cerebrospinal fluid (not shown), the liver, bone marrow, or lungs.

    In stage IV adult non-Hodgkin lymphoma, the cancer:

    • is found throughout one or more organs that are not part of a lymphatic area (lymph node group, tonsils and nearby tissue, thymus, or spleen), and may be in lymph nodes near those organs; or
    • is found in one organ that is not part of a lymphatic area and has spread to organs or lymph nodes far away from that organ; or
    • is found in the liver, bone marrow, cerebrospinal fluid (CSF), or lungs (other than cancer that has spread to the lungs from nearby areas).

    Adult non-Hodgkin lymphomas are also described based on how fast they grow and where the affected lymph nodes are in the body.

    Indolent or aggressive:

    • Indolent lymphomas: These tend to grow and spread slowly and have few symptoms.
    • Aggressive lymphomas: These grow and spread quickly and have severe symptoms. Lymphoblastic lymphoma, diffuse small noncleaved cell lymphoma /Burkitt lymphoma, and mantle cell lymphoma are three types of aggressive adult non-Hodgkin lymphoma. Aggressive lymphomas are seen more often in patients who are HIV -positive (AIDS -related lymphoma).

    Contiguous or noncontiguous:

    • Contiguous lymphomas: Lymphomas in which the lymph nodes with cancer are next to each other.
    • Noncontiguous lymphomas: Lymphomas in which the lymph nodes with cancer are not next to each other, but are on the same side of the diaphragm.

    There is no standard staging system for Waldenström macroglobulinemia.

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with Waldenström macroglobulinemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

    WebMD Public Information from the National Cancer Institute

    Last Updated: February 25, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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