How It Works
Mitotic inhibitors interfere with the cancer cell's ability to reproduce. They do this by stopping mitosis (a process by which a cell divides), or blocking enzymes that are needed for reproduction.
Mitotic inhibitors are
intravenous (IV) medicines. The type and extent of a
cancer determines the exact dose and schedule for taking these
Why It Is Used
Mitotic inhibitors slow or stop the growth and spread of cancer cells in
the body. They may be used to treat cancers, such as breast cancer, ovarian cancer, or testicular cancer.
How Well It Works
Mitotic inhibitors are effective antitumor medicines. But the type
and extent of a cancer determines how effectively these medicines slow or
stop the growth of cancer cells in the body.
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
- Usually the benefits of the medicine are more important than any minor side effects.
- Side effects may go away after you take the medicine for a while.
- If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.
Call911or other emergency services right away if you have:
Call your doctor right away if you have:
Common side effects of these medicines include:
Taking docetaxel may cause you to get acute myelogenous leukemia (AML). But this is very rare.
(Nab)-paclitaxel may cause low white-blood-cell counts, inflamed lung tissues, and sepsis.
Vinorelbine may cause serious problems with the large intestine, such as severe constipation, a blockage, a hole in the intestine, or dead tissue. These problems have caused some deaths.
See Drug Reference for a full list of side effects. (Drug Reference
is not available in all systems.)
What To Think About
While you are taking these medicines, you will have tests to check your blood cell counts and your liver function.
Mitotic inhibitors should not be taken by anyone who has liver problems, a low white-blood-cell count, or who has taken this medicine in the past.
Men who are taking (nab)-paclitaxel should not attempt to father a child.
You may not be able to become pregnant or father a child after taking these medicines. Talk with your doctor about fertility before starting treatment.
Estramustine shouldn't be taken with milk products or calcium-rich foods as the calcium can make it harder for your body to absorb this medicine. Estramustine shouldn't be used by people who have had an allergic reaction to estradiol or chemotherapy medicines like estramustine.
Ixabepilone should not be taken by people who are allergic to synthetic castor oil. Tell your doctor about all the medicines you take because ixabepilone can react with other medicines, vitamins, or herbal products. You will need to avoid drinking alcohol while taking this medicine.
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Advice for women
Do not use this medicine if you are pregnant, breast-feeding, or planning to get pregnant. If you need to use this medicine, talk to your doctor about how you can prevent pregnancy.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
Primary Medical Reviewer
||Sarah Marshall, MD - Family Medicine
Specialist Medical Reviewer
||Douglas A. Stewart, MD - Medical Oncology
Current as of
||January 14, 2014