Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Recurrent and Progressive Pancreatic Neuroendocrine Tumors
There is no established therapy for pancreatic neuroendocrine tumors that recur or progress after prior therapy. Deciding on further treatment depends on many factors, including:The specific cancer.Prior treatment.Site of recurrence.Individual patient considerations.Attempts at re-resection of local tumors that have recurred or metastatic lesions may offer palliation, when technically feasible. Intra-arterial chemotherapy is a consideration for patients with liver metastases. Patients with hepatic-dominant disease and substantial symptoms caused by tumor bulk or hormone-release syndromes may benefit from continuous-infusion intra-arterial chemotherapy or procedures that reduce hepatic arterial blood flow to metastases (hepatic arterial occlusion with embolization or with chemoembolization).[2,3,4,5,6,7] Such treatment may also be combined with systemic chemotherapy. A variety of systemic agents have shown biologic or palliative activity,[1,8] including:Somatostatin
Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®): Treatment - Patient Information [NCI] - To Learn More About Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)
For more information from the National Cancer Institute about pancreatic neuroendocrine tumors (NETs), see the following:Pancreatic Cancer Home PageUnderstanding Cancer Series: Targeted Therapies (Advances in Targeted Therapies)Targeted Cancer TherapiesFor general cancer information and other resources from the National Cancer Institute, see the following:What You Need to Know About™ CancerUnderstanding Cancer Series: CancerCancer StagingChemotherapy and You: Support for People With CancerRadiation Therapy and You: Support for People With CancerCoping with Cancer: Supportive and Palliative CareQuestions to Ask Your Doctor About CancerCancer LibraryInformation For Survivors/Caregivers/Advocates
Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Pancreatic Neuroendocrine Tumors
A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.Gastrinoma Treatment of gastrinoma may include supportive care and the following:For symptoms caused by too much stomach acid, treatment may be a drug that decreases the amount of acid made by the stomach.For a single tumor in the head of the pancreas:Surgery to remove the tumor.Surgery to cut the nerve that causes stomach cells to make acid and treatment with a drug that decreases stomach acid.Surgery to remove the whole stomach (rare).For a single tumor in the body or tail of the pancreas, treatment is usually surgery to remove the body or tail of the pancreas.For several tumors in the pancreas, treatment is usually surgery to remove the body or tail of the pancreas. If tumor remains after surgery, treatment may include either:Surgery to
Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®): Treatment - Health Professional Information [NCI] - About This PDQ Summary
Purpose of This SummaryThis PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of pancreatic neuroendocrine tumors (islet cell tumors). It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.Reviewers and UpdatesThis summary is reviewed regularly and updated as necessary by the PDQ Adult Treatment Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH). Board members review recently published articles each month to determine whether an article should:be discussed at a meeting,be cited with text, orreplace or update an existing article that is already cited.Changes to the summaries are
Pancreatic Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage IV Pancreatic Cancer Treatment
Treatment Options for Stage IV Pancreatic CancerTreatment options for stage IV pancreatic cancer include the following:Palliative therapy.Chemotherapy: gemcitabine; gemcitabine and erlotinib; or oxaliplatin, irinotecan, leucovorin, and fluorouracil (5-FU) (FOLFIRINOX).[1,2,3,4,5,6,7,8,9,10]Palliative therapyPalliative therapy for advanced pancreatic cancer includes the following:Pain-relieving procedures (e.g., celiac or intrapleural block) and supportive care.Palliative surgical biliary bypass, percutaneous radiologic biliary stent placement, or endoscopically placed biliary stents.[12,13,14]ChemotherapyThe low objective response rate and lack of survival benefit with current chemotherapy indicates that clinical trials are appropriate treatment of all newly diagnosed patients. Occasionally, patients have palliation of symptoms when treated with chemotherapy with well-tested older drugs, such as 5-FU. Gemcitabine has demonstrated activity in patients with pancreatic
Pancreatic Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - nci_ncicdr0000062951-nci-header
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Pancreatic Cancer Treatment
Pancreatic Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - General Information About Pancreatic Cancer
Related Summary Note: Another PDQ summary containing information related to pancreatic cancer includes: Unusual Cancers of Childhood (pancreatic cancer in children) Statistics Note: Estimated new cases and deaths from pancreatic cancer in the United States in 2010:[ 1 ] New cases: 43,140. Deaths: 36,800. Note: Some citations in the text of this section are followed by a level of evidence. The ...
Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Stages of Pancreatic Cancer
Tests and procedures to stage pancreatic cancer are usually done at the same time as diagnosis. The process used to find out if cancer has spread within the pancreas or to other parts of the body is called staging. The information gathered from the staging process determines the stage of the disease. It is important to know the stage of the disease in order to plan treatment. The results of some of the tests used to diagnose pancreatic cancer are often also used to stage the disease. See the General Information section for more information.There are three ways that cancer spreads in the body.The three ways that cancer spreads in the body are:Through tissue. Cancer invades the surrounding normal tissue.Through the lymph system. Cancer invades the lymph system and travels through the lymph vessels to other places in the body.Through the blood. Cancer invades the veins and capillaries and travels through the blood to other places in the body.When cancer cells break away from the primary
Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (03 / 07 / 2014)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Editorial changes were made to this summary.This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.
Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Recurrent Pancreatic Cancer
Treatment of recurrent pancreatic cancer may include the following:Palliative surgery or stent placement to bypass blocked areas in ducts or the small intestine.Palliative radiation therapy to shrink the tumor.Other palliative medical care to reduce symptoms, such as nerve blocks to relieve pain.Chemotherapy.Clinical trials of chemotherapy, new anticancer therapies, or biologic therapy.Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent pancreatic cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.