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Pancreatic Cancer Health Center

Medical Reference Related to Pancreatic Cancer

  1. Treatment Options for Recurrent Pancreatic Cancer

    Treatment of recurrent pancreatic cancer may include the following:Palliative surgery or stent placement to bypass blocked areas in ducts or the small intestine.Palliative radiation therapy to shrink the tumor.Other palliative medical care to reduce symptoms, such as nerve blocks to relieve pain.Chemotherapy.Clinical trials of chemotherapy, new anticancer therapies, or biologic therapy.Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent pancreatic cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

  2. Recurrent Pancreatic Cancer

    Recurrent pancreatic cancer is cancer that has recurred (come back) after it has been treated. The cancer may come back in the pancreas or in other parts of the body.

  3. Recurrent Pancreatic Cancer Treatment

    Treatment Options for Recurrent Pancreatic CancerTreatment options for recurrent pancreatic cancer include the following:Palliative therapy.Chemotherapy: fluorouracil [1] or gemcitabine.[2,3,4]Palliative therapyPalliative therapy for recurrent pancreatic cancer includes the following:Palliative surgical bypass procedures such as endoscopic or radiologically placed stents.[5,6]Palliative radiation procedures.Pain relief by celiac axis nerve or intrapleural block (percutaneous).[7]Other palliative medical care alone.ChemotherapyChemotherapy occasionally produces objective antitumor response, but the low percentage of significant responses and lack of survival advantage warrant use of therapies under evaluation.[8]Treatment Options Under Clinical Evaluation for Recurrent Pancreatic CancerTreatment options under clinical evaluation include the following:Phase I and II clinical trials evaluating pharmacologic modulation of fluorinated pyrimidines, new anticancer agents, or biological

  4. Stage III Pancreatic Cancer Treatment

    Treatment Options for Stage III Pancreatic CancerWhile stage III and stage IV pancreatic cancer are both incurable, the natural history of stage III (locally advanced) disease may be different than it is for stage IV disease. An autopsy series demonstrated that 30% of patients presenting with stage III disease died without evidence of distant metastases.[1][Level of evidence: 1iiA] Therefore, investigators have struggled with the question of whether chemoradiation for patients presenting with stage III disease is warranted.Treatment options for stage III pancreatic cancer include the following:Palliative surgery: palliative surgical biliary and/or gastric bypass, percutaneous radiologic biliary stent placement, or endoscopic biliary stent placement.[2,3]Chemoradiation therapy:Chemoradiation followed by chemotherapy.Chemotherapy followed by chemoradiation, for patients without metastatic disease.Chemotherapy: gemcitabine; gemcitabine and

  5. Treatment Options for Pancreatic Neuroendocrine Tumors

    A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.Gastrinoma Treatment of gastrinoma may include supportive care and the following:For symptoms caused by too much stomach acid, treatment may be a drug that decreases the amount of acid made by the stomach.For a single tumor in the head of the pancreas:Surgery to remove the tumor.Surgery to cut the nerve that causes stomach cells to make acid and treatment with a drug that decreases stomach acid.Surgery to remove the whole stomach (rare).For a single tumor in the body or tail of the pancreas, treatment is usually surgery to remove the body or tail of the pancreas.For several tumors in the pancreas, treatment is usually surgery to remove the body or tail of the pancreas. If tumor remains after surgery, treatment may include either:Surgery to

  6. Stage I and Stage II Pancreatic Cancer Treatment

    Treatment Options for Stages I and II Pancreatic CancerTreatment options for stages I and II pancreatic cancer include the following:Surgery: radical pancreatic resection including:Whipple procedure (pancreaticoduodenal resection).Total pancreatectomy when necessary for adequate margins.Distal pancreatectomy for tumors of the body and tail of the pancreas.[1,2]Postoperative chemoradiation therapy: radical pancreatic resection followed by 5-fluorouracil (5-FU) chemotherapy and radiation therapy.[3,4,5,6,7]Postoperative chemotherapy: radical pancreatic resection followed by chemotherapy (gemcitabine or 5-FU/leucovorin).[8]Surgery Complete resection can yield 5-year survival rates of 18% to 24%, but ultimate control remains poor because of the high incidence of both local and distant tumor recurrence.[9,10,11][Level of evidence: 3iA]Approximately 20% of patients present with pancreatic cancer amenable to local surgical resection, with operative mortality rates of

  7. Treatment Options by Stage

    A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.Stages I and II Pancreatic CancerTreatment of stage I and stage II pancreatic cancer may include the following:Surgery.Surgery followed by chemotherapy.Surgery followed by chemoradiation.A clinical trial of combination chemotherapy.A clinical trial of chemotherapy and targeted therapy, with or without chemoradiation.A clinical trial of chemotherapy and/or radiation therapy before surgery.Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I pancreatic cancer and stage II pancreatic cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about

  8. nci_ncicdr0000062951-nci-header

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Pancreatic Cancer Treatment

  9. Changes to This Summary (06 / 12 / 2013)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.This summary was reformatted.Stage I and Stage II Pancreatic Cancer TreatmentAdded text about a 5-year update of the Radiation Therapy Oncology Group (RTOG)-9704 trial, which reported that patients with pancreatic head tumors had a median survival and 5-year overall survival of 20.5 months and 22% survival rate with gemcitabine, versus 17.1 months and 18% with 5-fluorouracil. Also added text about a secondary analysis of RTOG-9704 that explored the correlation of adherence to protocol-specified radiation with patient outcomes. Added text to state that the European Organization for the Research and Treatment of Cancer/U.S. Gastrointestinal Intergroup (RTOG-0848) phase III adjuvant trial evaluating the impact of chemoradiation after completion of a full course of gemcitabine with or without

  10. Stage Information for Pancreatic Cancer

    The staging system for pancreatic exocrine cancer continues to evolve. The importance of staging beyond establishing whether a tumor is resectable is uncertain since state-of-the-art treatment has demonstrated little impact on survival. However, knowledge of the extent of the disease is necessary to communicate a uniform definition of disease. AJCC Stage Groupings and TNM DefinitionsThe American Joint Committee on Cancer (AJCC) has designated staging by TNM classification.[1]Table 1. Definitions of TNM Stage 0aStageTNMDescriptiona Reprinted with permission from AJCC: Exocrine and endocrine pancreas. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 241-9.b This also includes the pancreatic intraepithelial neoplasia (PanIN)-3 classification.0Tis, N0, M0Tis = Carcinomain situ.bN0 = No regional lymph node metastasis.M0 = No distant metastasis.Table 2. Definitions of TNM Stages IA and

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