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    Pancreatic Cancer Health Center

    Medical Reference Related to Pancreatic Cancer

    1. Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - General Information About Pancreatic Cancer

      Related Summary Note: Another PDQ summary containing information related to pancreatic cancer includes: Unusual Cancers of Childhood (pancreatic cancer in children) Statistics Note: Estimated new cases and deaths from pancreatic cancer in the United States in 2010:[ 1 ] New cases: 43,140. Deaths: 36,800. Note: Some citations in the text of this section are followed by a level of evidence. The ...

    2. Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Stage I and Stage II Pancreatic Cancer Treatment

      Treatment Options for Stages I and II Pancreatic CancerTreatment options for stages I and II pancreatic cancer include the following:Surgery: radical pancreatic resection including:Whipple procedure (pancreaticoduodenal resection).Total pancreatectomy when necessary for adequate margins.Distal pancreatectomy for tumors of the body and tail of the pancreas.[1,2]Postoperative chemoradiation therapy: radical pancreatic resection followed by 5-fluorouracil (5-FU) chemotherapy and radiation therapy.[3,4,5,6,7]Postoperative chemotherapy: radical pancreatic resection followed by chemotherapy (gemcitabine or 5-FU/leucovorin).[8]Surgery Complete resection can yield 5-year survival rates of 18% to 24%, but ultimate control remains poor because of the high incidence of both local and distant tumor recurrence.[9,10,11][Level of evidence: 3iA]Approximately 20% of patients present with pancreatic cancer amenable to local surgical resection, with operative mortality rates of

    3. Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Recurrent Pancreatic Cancer

      Recurrent pancreatic cancer is cancer that has recurred (come back) after it has been treated. The cancer may come back in the pancreas or in other parts of the body.

    4. Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - nci_ncicdr0000062951-nci-header

      This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Pancreatic Cancer Treatment

    5. Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Stage IV Pancreatic Cancer Treatment

      Treatment Options for Stage IV Pancreatic CancerTreatment options for stage IV pancreatic cancer include the following:Palliative therapy.Chemotherapy: gemcitabine; gemcitabine and erlotinib; or oxaliplatin, irinotecan, leucovorin, and fluorouracil (5-FU) (FOLFIRINOX).[1,2,3,4,5,6,7,8,9,10]Palliative therapyPalliative therapy for advanced pancreatic cancer includes the following:Pain-relieving procedures (e.g., celiac or intrapleural block) and supportive care.[11]Palliative surgical biliary bypass, percutaneous radiologic biliary stent placement, or endoscopically placed biliary stents.[12,13,14]ChemotherapyThe low objective response rate and lack of survival benefit with current chemotherapy indicates that clinical trials are appropriate treatment of all newly diagnosed patients. Occasionally, patients have palliation of symptoms when treated with chemotherapy with well-tested older drugs, such as 5-FU. Gemcitabine has demonstrated activity in patients with pancreatic

    6. Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Option Overview

      There are different types of treatment for patients with pancreatic cancer. Different types of treatment are available for patients with pancreatic cancer. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment. Five types of standard treatment are used:Surgery One of the following types of surgery may be used to take out the tumor:Whipple procedure: A surgical procedure in which the head of the pancreas, the gallbladder, part of the stomach, part of the small intestine, and the bile duct are removed.

    7. Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Insulinoma

      Curative surgical excision, by open laparotomy or laparoscopy, is the treatment of choice when possible. The open surgical approach is used if the tumor is suspected to be malignant, since en bloc lymphadenectomy is performed for malignant tumors without distant metastases. Intraoperative ultrasound aids the localization of tumor extent and the relationship to other anatomic structures.[1]Standard treatment options:Single small lesion in head or tail of pancreas:[1,2,3,4]Enucleation, if feasible. Large lesion in the head of the pancreas that is not amenable to enucleation:[1,2,3,4]Pancreaticoduodenectomy.Single large lesion in body/tail:[1,2,3,4]Distal pancreatectomy.Multiple lesions: occur in 10%, often in association with multiple endocrine neoplasia syndrome type 1 (MEN-1):[1,2,3,4]Distal pancreatectomy with enucleation of tumors in the head of the pancreas.Metastatic lesions: lymph nodes or distant sites:[5,6,7,8,9,10,11,12]Resect when possible.Consider radiofrequency or

    8. Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - About This PDQ Summary

      Purpose of This SummaryThis PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of pancreatic cancer. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.Reviewers and UpdatesThis summary is reviewed regularly and updated as necessary by the PDQ Adult Treatment Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH). Board members review recently published articles each month to determine whether an article should:be discussed at a meeting,be cited with text, orreplace or update an existing article that is already cited.Changes to the summaries are made through a consensus process in

    9. Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - nci_ncicdr0000062957-nci-header

      This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Pancreatic Cancer Treatment

    10. Pancreatic Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Changes to This Summary (03 / 07 / 2014)

      The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Editorial changes were made to this summary.This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

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