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Cellular Classification of Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)

    Table 1. Endocrine Tumors of the Pancreas

    Islet CellsSecreted Active AgentTumor and Syndrome
    ACTH = adrenocorticotropin; MSH = melanocyte-stimulating hormone; VIP = vasoactive intestinal peptide; WDHA = watery diarrhea, hypokalemia, and achlorhydria; 5-HT = serotonin.
    AlphaGlucagonGlucagonoma (diabetes, dermatitis)
    BetaInsulinInsulinoma (hypoglycemia)
    DeltaSomatostatinSomatostatinoma (mild diabetes); diarrhea/steatorrhea; gallstones
    DGastrinGastrinoma (peptic ulcer disease)
    A -> DVIP and/or other undefined mediatorsWDHA
    5-HT
    ACTH
    MSHCarcinoid
    Cushing syndrome
    Hyperpigmentation
    Interacinar CellsSecreted Active AgentTumor and Syndrome
    FPancreatic polypeptideMultiple hormonal syndromes
    EC5-HTCarcinoid

      This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

      WebMD Public Information from the National Cancer Institute

      Last Updated: February 25, 2014
      This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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