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    Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular Classification of Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)

    Table 1. Endocrine Tumors of the Pancreas

    Islet Cells Secreted Active Agent Tumor and Syndrome
    ACTH = adrenocorticotropin; MSH = melanocyte-stimulating hormone; VIP = vasoactive intestinal peptide; WDHA = watery diarrhea, hypokalemia, and achlorhydria; 5-HT = serotonin.
    Alpha Glucagon Glucagonoma (diabetes, dermatitis)
    Beta Insulin Insulinoma (hypoglycemia)
    Delta Somatostatin Somatostatinoma (mild diabetes); diarrhea/steatorrhea; gallstones
    D Gastrin Gastrinoma (peptic ulcer disease)
    A -> D VIP and/or other undefined mediators WDHA
    5-HT
    ACTH
    MSH Carcinoid
    Cushing syndrome
    Hyperpigmentation
    Interacinar Cells Secreted Active Agent Tumor and Syndrome
    F Pancreatic polypeptide Multiple hormonal syndromes
    EC 5-HT Carcinoid

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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