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Pancreatic Cancer Health Center

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Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular Classification of Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)

Table 1. Endocrine Tumors of the Pancreas

Islet CellsSecreted Active AgentTumor and Syndrome
ACTH = adrenocorticotropin; MSH = melanocyte-stimulating hormone; VIP = vasoactive intestinal peptide; WDHA = watery diarrhea, hypokalemia, and achlorhydria; 5-HT = serotonin.
AlphaGlucagonGlucagonoma (diabetes, dermatitis)
BetaInsulinInsulinoma (hypoglycemia)
DeltaSomatostatinSomatostatinoma (mild diabetes); diarrhea/steatorrhea; gallstones
DGastrinGastrinoma (peptic ulcer disease)
A -> DVIP and/or other undefined mediatorsWDHA
Cushing syndrome
Interacinar CellsSecreted Active AgentTumor and Syndrome
FPancreatic polypeptideMultiple hormonal syndromes

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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