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    Pancreatic Neuroendocrine Tumors (NETs)

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    Causes

    No one knows what causes pancreatic NETs. People who have family members with a disorder called multiple endocrine neoplasia type 1 (MEN1), which can also affect the pancreas, are more likely to get them.

    Other tumor-causing diseases that are passed down in families also raise your chances, including:

    • Von Hippel-Lindau syndrome
    • Neurofibromatosis type 1
    • Tuberous sclerosis

    Symptoms

    Because nonfunctional NETs often don't cause symptoms until they become large or spread, doctors usually find them at a later stage.

    You may have problems like:

    • Diarrhea
    • Uncomfortable feeling of fullness after eating
    • Lump in your belly
    • Pain in your belly or back
    • Yellowish skin or eyes

    The symptoms of a functional NET depend on the kind of hormone it makes. You might feel:

    • Tired
    • Nervous or anxious
    • Confused
    • Shaky, dizzy, or lightheaded
    • Thirsty
    • More or less hungry than usual

    You could have:

    • Weight loss or gain
    • Diarrhea
    • A need to go to the bathroom more or less
    • Pain in a specific place that won't go away
    • A backup of stomach acid into your throat
    • Cough
    • Headache
    • Trouble seeing
    • Fast heartbeat
    • Sweating a lot
    • Raised, red rash on your lower leg, around your mouth, or anywhere your skin rubs together

    Getting a Diagnosis

    Before you get any tests, your doctor may have some questions for you. He'll want to know:

    • How have you been feeling?
    • When did you first notice changes?
    • Do you have pain and where?
    • How is your appetite?
    • Have you been thirsty?
    • Have you lost any weight?
    • Have you noticed any skin rashes?
    • Are you more tired than usual and when did this start?
    • Do you have any medical conditions?
    • Do you take any medications?
    • Does anyone in your family have an endocrine disorder? What type?
    • Do any illnesses run in your family?

    Your doctor will do a physical exam and may order some tests that can check where your tumor is growing. Some that you might get are:

    X-rays. They use radiation in low doses to make pictures of the inside of your body.

    Blood and urine tests. They check your levels of hormones and protein.

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    IMPORTANT SAFETY INFORMATION
    Who should not take SOMATULINE DEPOT?

    Do not take SOMATULINE DEPOT if you are allergic to lanreotide.

    What are the possible side effects of SOMATULINE DEPOT?

    SOMATULINE DEPOT may cause serious side effects, including:

    • Gallstones. Tell your healthcare professional if you get any of these symptoms:
      • sudden pain in your upper right stomach area (abdomen)
      • sudden pain in your right shoulder or between your shoulder blades
      • yellowing of your skin and whites of your eyes
      • fever with chills
      • nausea
    • Changes in your blood sugar (high blood sugar or low blood sugar). If you have diabetes, test your blood sugar as your healthcare professional tells you to. Your healthcare professional may change your dose of diabetes medicine.
    • Slow heart rate
    • High blood pressure

    The most common side effects of SOMATULINE DEPOT in people with GEP-NETs include stomach area (abdominal) pain, muscle and joint aches, vomiting, headache, and pain, itching, or a lump at the injection site.

    SOMATULINE DEPOT may cause dizziness. If this happens, do not drive a car or operate machinery.

    What should I tell my healthcare professional before receiving SOMATULINE DEPOT?
    • Tell your healthcare professional if you have diabetes or gallbladder, thyroid, heart, kidney, or liver problems.
    • Tell your healthcare professional if you are pregnant or plan to become pregnant as SOMATULINE DEPOT may harm your unborn baby. Tell your healthcare professional if you are breastfeeding or plan to breastfeed. It is not known if SOMATULINE DEPOT passes into your breast milk. You and your healthcare professional should decide if you will take SOMATULINE DEPOT or breastfeed. You should not do both.
    • Tell your healthcare professional about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SOMATULINE DEPOT and other medicines may affect each other, causing side effects. SOMATULINE DEPOT may affect the way other medicines work, and other medicines may affect how SOMATULINE DEPOT works.
    • Especially tell your healthcare professional if you take insulin or other diabetes medicines, a cyclosporine (Gengraf, Neoral, or Sandimmune), a medicine called bromocriptine (Parlodel, Cycloset), or medicines that lower your heart rate, such as beta blockers.

    Tell your healthcare professional if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of SOMATULINE DEPOT. For more information ask your healthcare professional.

    You may report side effects to FDA at 1-800-FDA-1088 or Ipsen Biopharmaceuticals, Inc. at 1-888-980-2889.

    Please click here for Patient Information and full
    Prescribing Information.

    Somatuline Depot is a registered trademark of Ipsen Pharma S.A.S.
    All other trademarks are the property of their respective owners.
    ©2015 Ipsen Biopharmaceuticals, Inc. November 2015. SMD-US-000105


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