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    Acupuncture (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Human / Clinical Studies

    Table 5. Clinical Studies of Acupuncture: Radiation-induced Xerostomiaa

    Reference Citation(s) Type of Study Condition Treated No. of Patients: Enrolled; Treated; Controlb Strongest Benefit Reportedc Concurrent Therapy (Yes/No/ Unknown)d Level of Evidence Scoree
    CT = controlled trial; No. = number; RCT = randomized controlled trial.
    a Refer to text and theNCI Dictionary of Cancer Termsfor additional information and definition of terms.
    b Number of patients treated plus number of patient controls may not equal number of patients enrolled; number of patients enrolled equals number of patients initially considered by the researcher who conducted a study; number of patients treated equals number of enrolled patients who were given the treatment being studied AND for whom results were reported.
    c Strongest evidence reported that the treatment under study has anticancer activity or otherwise improves the well-being of cancer patients.
    d Concurrent therapy for symptoms treated (not cancer).
    e For information about levels of evidence analysis and an explanation of the level of evidence scores, refer toLevels of Evidence for Human Studies of Cancer Complementary and Alternative Medicine.
    [61] RCT Radiation-induced xerostomia 12; 12; sham: non-active acupuncture points located 2 cm away from real points Improved symptoms Unknown 1iiC
    [60] RCT Radiation-induced xerostomia 38; 20; 18 Increased salivary flow rates Unknown 1iiC
    [63] RCT Xerostomia 21; 11; 10 Increased salivary flow rates Unknown 1iiC
    [56] RCT Radiation-induced xerostomia 23; 11; 12 Increased salivary flow rates Unknown 1iiC
    [56] RCT Radiation-induced xerostomia 86; 40; 46 Symptoms improved Unknown 1iiC
    [58] RCT with crossover Radiation-induced xerostomia 145; 75; 70 Symptoms improved No 1iiC
    [64] Pilot study Radiation-induced xerostomia 20; 19; none Improved symptoms Unknown 2C
    [65] CT Radiation-induced xerostomia 12; 12; none Symptoms improved Unknown 2C
    [66] CT Radiation-induced xerostomia 12; 12; none Symptoms improved Unknown 2C
    [67] CT Radiation-induced xerostomia 18; 18; none Reduced xerostomia Yes (pilocarpine) 2C
    [62] CT Xerostomia 70; 21; none Reduced xerostomia Unknown 2C
    [68] CT Xerostomia 17; 14; none Increased salivary flow rates Unknown 2C
    [69] CT Xerostomia 20; 20; none Symptoms improved Unknown 2C
    [70] CT Xerostomia 17; 10; none Increased salivary flow rates Unknown 2C
    [71] Nonconsecutive case series Xerostomia 14; 8 acupuncture; none Symptoms improved No 3iiiC
    [9] Nonconsecutive case series Xerostomia after radiation therapy in patients with cancer 13; 13 acupuncture; none Symptoms improved Yes (not specified) 3iiiC
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