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Acupuncture (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Human / Clinical Studies

Table 5. Clinical Studies of Acupuncture: Radiation-induced Xerostomiaa

Reference Citation(s)Type of StudyCondition TreatedNo. of Patients: Enrolled; Treated; ControlbStrongest Benefit ReportedcConcurrent Therapy (Yes/No/ Unknown)dLevel of Evidence Scoree
CT = controlled trial; No. = number; RCT = randomized controlled trial.
a Refer to text and theNCI Dictionary of Cancer Termsfor additional information and definition of terms.
b Number of patients treated plus number of patient controls may not equal number of patients enrolled; number of patients enrolled equals number of patients initially considered by the researcher who conducted a study; number of patients treated equals number of enrolled patients who were given the treatment being studied AND for whom results were reported.
c Strongest evidence reported that the treatment under study has anticancer activity or otherwise improves the well-being of cancer patients.
d Concurrent therapy for symptoms treated (not cancer).
e For information about levels of evidence analysis and an explanation of the level of evidence scores, refer toLevels of Evidence for Human Studies of Cancer Complementary and Alternative Medicine.
[61]RCTRadiation-induced xerostomia12; 12; sham: non-active acupuncture points located 2 cm away from real pointsImproved symptomsUnknown1iiC
[60]RCTRadiation-induced xerostomia38; 20; 18Increased salivary flow ratesUnknown1iiC
[63]RCTXerostomia21; 11; 10Increased salivary flow ratesUnknown1iiC
[56]RCTRadiation-induced xerostomia23; 11; 12Increased salivary flow ratesUnknown1iiC
[56]RCTRadiation-induced xerostomia86; 40; 46Symptoms improvedUnknown1iiC
[58]RCT with crossoverRadiation-induced xerostomia145; 75; 70Symptoms improvedNo1iiC
[64]Pilot studyRadiation-induced xerostomia20; 19; noneImproved symptomsUnknown2C
[65]CTRadiation-induced xerostomia12; 12; noneSymptoms improvedUnknown2C
[66]CTRadiation-induced xerostomia12; 12; noneSymptoms improvedUnknown2C
[67]CTRadiation-induced xerostomia18; 18; noneReduced xerostomiaYes (pilocarpine)2C
[62]CTXerostomia70; 21; noneReduced xerostomiaUnknown2C
[68]CTXerostomia17; 14; noneIncreased salivary flow ratesUnknown2C
[69]CTXerostomia20; 20; noneSymptoms improvedUnknown2C
[70]CTXerostomia17; 10; noneIncreased salivary flow ratesUnknown2C
[71]Nonconsecutive case seriesXerostomia14; 8 acupuncture; noneSymptoms improvedNo3iiiC
[9]Nonconsecutive case seriesXerostomia after radiation therapy in patients with cancer13; 13 acupuncture; noneSymptoms improvedYes (not specified)3iiiC
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