Local recurrences and/or persistent disease after treatment with radiation therapy and chemotherapy or surgery as the primary treatment may be controlled by using the alternate treatment (surgical resection after radiation and vice versa). Clinical trials are exploring the use of radiation therapy with chemotherapy and/or radiosensitizers to improve local control.
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent anal cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
Longo WE, Vernava AM 3rd, Wade TP, et al.: Recurrent squamous cell carcinoma of the anal canal. Predictors of initial treatment failure and results of salvage therapy. Ann Surg 220 (1): 40-9, 1994.
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WebMD Public Information from the National Cancer Institute
September 04, 2014
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