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Cancer Health Center

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Cancer Genetics Overview (PDQ®): Genetics - Health Professional Information [NCI] - Genetic Resources

Health care providers who deliver genetic services, including genetic counseling, can be located through local, regional, and national professional genetics organizations and through NCI's Cancer Genetics Services Directory Web site. Providers of cancer genetic services are not limited to one specialty and include medical geneticists, genetic counselors, advanced practice genetics nurses, oncologists (medical, radiation, or surgical), other surgeons, internists, pediatricians, family practitioners, and mental health professionals. A cancer genetics health care provider will assist in constructing and evaluating a pedigree, eliciting and evaluating personal and family medical histories, and calculating and providing information about cancer risk and/or probability of a mutation being associated with cancer in the family. In addition, if a genetic test is available, these providers can assist in pretest counseling, laboratory selection, informed consent, test interpretation, posttest counseling, and follow-up.

Table 1. Clinical Genetics Information

Human Genome Epidemiology Network (HuGENet)Network for sharing population-based human genome epidemiologic information.
National Institutes of Health Genetic Testing Registry (GTR)Central location for voluntary submission of genetic test information by providers. The scope includes the test's purpose, methodology, validity, evidence of the test's usefulness, and laboratory contacts and credentials.
Online Mendelian Inheritance in Man (OMIM)Catalog of humangenesand genetic disorders.

Table 2. Clinical Management Information

Clinical Practice Guidelines from the American College of Medical Genetics (ACMG)Clinical practice guidelines developed by expert panels forrisk assessment, testing, and counseling of individuals with various inherited conditions, including some cancers, or individuals with a high risk of developing these conditions.
Clinical Practice Guidelines from the American Society of Clinical Oncology (ASCO)Clinical practice guidelines developed by expert panels for specific clinical situations (disease-oriented) or use of approved medical products, procedures, or tests (modality-oriented).
National Comprehensive Cancer Network (NCCN) GuidelinesClinical practice guidelines developed by expert panels that detail the sequential management decisions and interventions for the malignant cancers that affect 97% of all patients with cancer. In addition, separate guidelines relate to major prevention and screening topics, and another set of pathways focuses on the major supportive care areas.
National Guideline Clearinghouse from the Agency for Healthcare Research and Quality (AHRQ)A public resource for evidence-based clinical practice guidelines.
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