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Cancer Genetics Overview (PDQ®): Genetics - Health Professional Information [NCI] - Genetic Resources

Table 5. Family History Tools

ResourceDescription
Family Health History (Genetic Alliance)Tips for collectingfamily historyinformation and links to resources.
Family History Public Health Initiative (Centers for Disease Control and Prevention)Web site devoted to using family history to promote health.
Family Medical History (American Medical Association)Tools for gathering family history and links to resources.
My Family Health Portrait (U.S. Surgeon General)Web-based family history tool.
Your Family History (National Society of Genetic Counselors)Information on collecting a family health history.

Table 6. Genome Research Information

ResourceDescription
BLAST = Basic Local Alignment Search Tool; COSMIC = Catalogue Of Somatic Mutations In Cancer; iHOP = information hyperlinked over proteins; SARS = severe acute respiratory syndrome; SNPs = single nucleotide polymorphisms; UCSC = University of California, Santa Cruz.
BLAST Search (part of the Ensembl Project; see below)Search protein or DNA sequence against metazoan genomes.
The Cancer Genome Anatomy Project (CGAP)Access to all CGAP data and biological resources.
CancerGenesCombines gene lists annotated by experts with information from key public databases such asEntrez Gene,COSMIC, andiHOP.
Cancer Genome Workbench (CGWB)Integrates clinical tumor mutation profiles with the reference human genome to improve the accuracy of mutation identification.
Chromosomal Variation in ManSearchable database of literature citations on chromosomal variants and anomalies.
Ensembl (Joint software project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute)Data sets resulting from an automated genome analysis and annotation process.
Genome ChannelJava viewers for human genome data.
Genome Sequencing Center: Homo sapiens MapsLinks tocloneand accession maps of the human genome.
International Cancer Genome Consortium Data PortalA collection of genome data from more than 25 cancer projects consisting of over 3,500 tumor genomes from 13 cancer types and subtypes. Most data are available with open access.
International HapMap ProjectA variety of ways to query for SNPs in the human genome.
Leiden Open Variation DatabaseA flexible, free tool for gene-centered collection, curation, and display of DNA variation.
KMcancerDBHuman gene mutation database with graphical display of molecular information for cancer-related genes.
National Center for Biotechnology Information: Genomic BiologyViews of chromosomes, maps, and loci; links to other NCBI resources.
Online Mendelian Inheritance in Man (OMIM)Catalog of human genes and genetic disorders.
UCSC Genome BioinformaticsReference sequence for the human andC. elegansgenomes and working drafts for the mouse, rat, Fugu, Drosophila,C. briggsae, yeast, and SARS genomes.
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