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Cancer Health Center

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Cardiopulmonary Syndromes (PDQ®): Supportive care - Patient Information [NCI] - Superior Vena Cava Syndrome

Superior vena cava syndrome (SVCS) is a group of signs and symptoms that occur when the superior vena cava is partly blocked.

The superior vena cava is a major vein that leads to the heart. The heart is divided into four parts. The right and left atrium make up the top parts of the heart and the right and left ventricle make up the bottom parts of the heart. The right atrium of the heart receives blood from two major veins:

  • The superior vena cava returns blood from the upper body to the heart.
  • The inferior vena cava returns blood from the lower body to the heart.

Different conditions can slow the flow of blood through the superior vena cava. These include a tumor in the chest, nearby lymph nodes that are swollen (from cancer), or a blood clot in the superior vena cava. The vein may become completely blocked. Sometimes, smaller veins in the area become larger and take over for the superior vena cava if it is blocked, but this takes time. Superior vena cava syndrome (SVCS) is the group of signs and symptoms that occur when this vein is partly blocked.

SVCS is usually caused by cancer.

Superior vena cava syndrome (SVCS) is usually caused by cancer. In adults, SVCS is most common in the following types of cancer:

Less common causes of SVCS include:

  • A blood clot that forms during the use of an intravenous catheter (flexible tube used to put fluids into or take blood out of a vein) in the superior vena cava. A clot may also be caused by pacemaker wires.
  • Infection or cancer in the chest that causes affected tissues to become thick and hard.
  • Other cancers, including metastatic breast cancer, metastatic germ cell tumors, colon cancer, esophageal cancer, Kaposi sarcoma, Hodgkin lymphoma, thymus cancer, and thyroid cancer.
  • Behcet syndrome (a disease of the immune system).
  • Sarcoidosis (a disease of the lymph nodes that acts like tuberculosis).

Common signs and symptoms of SVCS include breathing problems and coughing.

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