Metastases at diagnosis are detected in approximately 25% of patients. The prognosis of patients with metastatic disease is poor. Current therapies for patients who present with metastatic disease achieve 6-year event-free survival (EFS) of approximately 28% and overall survival (OS) of approximately 30%.[2,3] For patients with lung/pleural metastases only, 6-year EFS is approximately 40% when utilizing bilateral lung irradiation.[2,4] In contrast, patients with bone/bone marrow metastases have...
Revised text to state that the pilot study showed a 5-year event-free survival rate of 73% for all patients receiving nelarabine and 69% for those patients with a slow early response (cited Dunsmore et al. as reference 10).
Added Ram et al. as reference 32.
Treatment of Recurrent Childhood ALL
Added Leung et al. as reference 54.
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