A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your child's doctor for clinical trials that are not listed here but may be right for your child.
The PDQ editorial boards use a ranking system of levels of evidence to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. For any given therapy, results of prevention and treatment studies can be ranked on each of the following two scales:
Strength of the study design.
Strength of the endpoints.
Together, the two rankings provide a measure of the overall level of evidence. Screening studies are ranked on strength of study design alone...
Treatment of standard-risk childhood acute lymphoblastic leukemia (ALL) during the induction, consolidation /intensification, and maintenance phases may include the following:
Combination chemotherapy followed by stem cell transplant using stem cells from a donor.
A clinical trial of a new chemotherapy regimen.
A clinical trial of a new combination chemotherapy and intrathecal chemotherapy regimen given with or without radiation therapy and/or stem cell transplant. The chemotherapy dose and/or schedule depends on the patient's risk group after induction therapy.
CNS-directed therapy to treat or prevent the spread of leukemia cells to the brain and spinal cord may include the following:
High-dose systemic chemotherapy.
A clinical trial of a new anticancer drug, the doses of certain anticancer drugs, and the use of radiation therapy to the brain.
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with untreated childhood acute lymphoblastic leukemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.