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Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Childhood Acute Lymphoblastic Leukemia

Newly Diagnosed Childhood Acute Lymphoblastic Leukemia (Standard Risk)

The treatment of standard-risk childhood acute lymphoblastic leukemia (ALL) during the remission induction, consolidation /intensification, and maintenance phases always includes combination chemotherapy. Children who are not in remission after having combination chemotherapy during the induction phase may be helped by more chemotherapy. When they are in remission, a stem cell transplant using stem cells from a donor may be done.

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Understanding Leukemia -- Symptoms

Many types of leukemia produce no obvious symptoms in the early stages. Eventually, symptoms may include any of the following: Anemia and related symptoms, such as fatigue, pallor, and a general feeling of illness. A tendency to bruise or bleed easily, including bleeding from the gums or nose, or blood in the stool or urine. Susceptibility to infections such as sore throat or bronchial pneumonia, which may be accompanied by headache, low-grade fever, mouth sores, or skin rash. ...

Read the Understanding Leukemia -- Symptoms article > >

Intrathecal chemotherapy is given to prevent the spread of leukemia cells to the brain and spinal cord.

Treatments being studied in clinical trials for standard-risk ALL include new chemotherapy regimens.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with untreated childhood acute lymphoblastic leukemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

Newly Diagnosed Childhood Acute Lymphoblastic Leukemia (High Risk)

The treatment of high-risk childhood acute lymphoblastic leukemia (ALL) during the remission induction, consolidation /intensification, and maintenance phases always includes combination chemotherapy. Children in the high-risk ALL group are given more anticancer drugs and higher doses of anticancer drugs, especially during the consolidation/intensification phase, than children in the standard-risk group.

Intrathecal and systemic chemotherapy are given to prevent the spread of leukemia cells to the brain and spinal cord. Sometimes radiation therapy to the brain is also given.

Treatments being studied in clinical trials for high-risk ALL include new chemotherapy regimens and stem cell transplant.

Newly Diagnosed Childhood Acute Lymphoblastic Leukemia (Special Groups)

T-cell childhood acute lymphoblastic leukemia

The treatment of T-cell childhood acute lymphoblastic leukemia (ALL) during the remission induction, consolidation /intensification, and maintenance phases always includes combination chemotherapy. Children with T-cell ALL are given more anticancer drugs and higher doses of anticancer drugs than children with B-cell ALL in the standard-risk group.

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