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    Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Childhood Acute Lymphoblastic Leukemia

    Newly Diagnosed Childhood Acute Lymphoblastic Leukemia (Standard Risk)

    The treatment of standard-risk childhood acute lymphoblastic leukemia (ALL) during the remission induction, consolidation /intensification, and maintenance phases always includes combination chemotherapy. Children who are not in remission after having combination chemotherapy during the induction phase may be helped by more chemotherapy. When they are in remission, a stem cell transplant using stem cells from a donor may be done.

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    Understanding Leukemia -- the Basics

    Leukemia is an abnormal rise in the number of white blood cells. The white blood cells crowd out other blood cell elements such as red blood cells and platelets. The elevated white blood cells are immature and do not function properly. Leukemia -- the term derives from the Greek words for "white" and "blood" -- is often considered a disease of children, yet it actually affects far more adults. It is more common in men than women and in Caucasians than African-Americans. There will be more than...

    Read the Understanding Leukemia -- the Basics article > >

    Intrathecal chemotherapy is given to prevent the spread of leukemia cells to the brain and spinal cord.

    Treatments being studied in clinical trials for standard-risk ALL include new chemotherapy regimens.

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with untreated childhood acute lymphoblastic leukemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

    Newly Diagnosed Childhood Acute Lymphoblastic Leukemia (High Risk)

    The treatment of high-risk childhood acute lymphoblastic leukemia (ALL) during the remission induction, consolidation /intensification, and maintenance phases always includes combination chemotherapy. Children in the high-risk ALL group are given more anticancer drugs and higher doses of anticancer drugs, especially during the consolidation/intensification phase, than children in the standard-risk group.

    Intrathecal and systemic chemotherapy are given to prevent the spread of leukemia cells to the brain and spinal cord. Sometimes radiation therapy to the brain is also given.

    Treatments being studied in clinical trials for high-risk ALL include new chemotherapy regimens and stem cell transplant.

    Newly Diagnosed Childhood Acute Lymphoblastic Leukemia (Special Groups)

    T-cell childhood acute lymphoblastic leukemia

    The treatment of T-cell childhood acute lymphoblastic leukemia (ALL) during the remission induction, consolidation /intensification, and maintenance phases always includes combination chemotherapy. Children with T-cell ALL are given more anticancer drugs and higher doses of anticancer drugs than children with B-cell ALL in the standard-risk group.

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