The major challenge in treating plasma cell neoplasms is to separate the stable, asymptomatic group of patients who do not require immediate treatment from patients with progressive, symptomatic myeloma who should be treated immediately.[1,2] Monoclonal gammopathy of undetermined significance or smoldering myeloma must be distinguished from progressive myeloma.
Asymptomatic Plasma Cell Neoplasms
Asymptomatic patients with multiple myeloma who have no lytic bone lesions and normal renal function...
Revised text to state that for a full description of the classification of nervous system tumors and a link to the corresponding treatment summary for each type of brain tumor, refer to the PDQ summary on Childhood Brain and Spinal Cord Tumors Treatment Overview.
The Predictors of Outcome subsection was extensively revised.
Cellular Classification of Central Nervous System (CNS) Embryonal Tumors
Added Taylor et al. as reference 27.
Added text about the characteristics of Gorlin syndrome, including the associated mutations and diseases, predisposition to basal cell carcinomas, and the diagnostic features (cited Brugières et al. and Pastorino et al. as references 28 and 29, respectively).
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