The initial approach to the patient is to evaluate the following parameters:
Detection of a monoclonal (or myeloma) protein (M protein) in the serum or urine.
Detection of more than 10% of plasma cells on a bone marrow examination.
Detection of lytic bone lesions or generalized osteoporosis in skeletal x-rays.
Presence of soft tissue plasmacytomas.
Serum albumin and beta-2-microglobulin levels.
Detection of free kappa and lambda serum immunoglobulin light...
Revised text to state that for a full description of the classification of nervous system tumors and a link to the corresponding treatment summary for each type of brain tumor, refer to the PDQ summary on Childhood Brain and Spinal Cord Tumors Treatment Overview.
The Predictors of Outcome subsection was extensively revised.
Cellular Classification of Central Nervous System (CNS) Embryonal Tumors
Added Taylor et al. as reference 27.
Added text about the characteristics of Gorlin syndrome, including the associated mutations and diseases, predisposition to basal cell carcinomas, and the diagnostic features (cited Brugières et al. and Pastorino et al. as references 28 and 29, respectively).
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