Pheochromocytomas and extra-adrenal paragangliomas are rare tumors arising from neural crest tissue that develops into sympathetic and parasympathetic paraganglia throughout the body.
The most recent World Health Organization classification utilizes the term pheochromocytoma exclusively for tumors arising from the adrenal medulla, and the term extra-adrenal paraganglioma for similar tumors that arise from other locations.
Incidence and Mortality
The incidence of pheochromocytoma is 2...
Treatment Options for Newly Diagnosed Childhood Craniopharyngioma
Added Clark et al. as reference 8.
Revised text to state that the surgical procedure is followed by radiation therapy, with a 5-year progression-free survival rate of about 70% to 90% and 10-year overall survival rates higher than 90% (cited Merchant et al. as reference 12 and level of evidence 3iDiii). Also added text to state that transient cyst enlargement may be noted soon after radiation therapy but generally resolves without further intervention (cited Shi et al. as reference 14 and level of evidence 3iDiv).
Added Kickingereder et al. as reference 24 and level of evidence 2A.
Treatment Options for Recurrent Childhood Craniopharyngioma
Added text to state that although systemic therapy is generally not utilized, a small series has shown that the use of subcutaneous pegylated interferon alpha-2b to manage cystic recurrences can result in durable response (cited Yeung et al. as reference 7 and level of evidence 3iiiDiii).
This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.
In this article
This information is produced and provided by the National
Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National
Institute via the Internet web site at http://
.gov or call 1-800-4-CANCER.
WebMD Public Information from the National Cancer Institute
September 04, 2014
This information is not intended to replace the advice of a doctor.
Healthwise disclaims any liability for the decisions you make based on this