Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Cancer Health Center

Font Size

Childhood Liver Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (09 / 08 / 2014)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

General Information

Added text to state that between 1975 and 2010, childhood cancer mortality decreased by more than 50% (cited Smith et al. as reference 1).

Added text to state that neonates with hepatoblastoma have comparable outcomes to older children up to age 5 years (cited Trobaugh-Lotrario et al. as reference 13). Also revised text to state that the overall 5-year survival rate is 42% for those with hepatocellular carcinoma.

Revised Table 1 to include Aicardi syndrome as a disorder associated with hepatoblastoma (cited Kamien et al. as reference 15).

Added Spector et al. as reference 26.

Cellular Classification

Added text to state that fibrolamellar carcinoma histology is characterized by a fusion transcript created by deletion of a 400 kb section of chromosome 19, which was found in 15 of 15 tumors that were tested (cited Honeyman et al. as reference 13).

Added Weeda et al. reference 18 and level of evidence 3iiA.

Added Olson et al. as reference 23.

Stage Information

Added text to state that revisions and radiologic examples of the PRETEXT staging system were published in 2007 (cited Roebuck et al. as reference 5).

Treatment Option Overview

Revised text to state that the International Society of Pediatric Oncology Epithelial Liver Tumor Group (SIOPEL) has reported a pilot study of high-risk hepatoblastoma patients; in SIOPEL-3HR, cisplatin alternating with carboplatin/doxorubicin was administered in a dose intensive fashion. Also added text to state that in a second trial, cisplatin was dose-intensified in a single-arm prospective study; 3-year event-free survival (EFS) was 76% and overall survival (OS) was 83%; toxicity was significant but acceptable (cited 2013 Zsiros et al. as reference 28 and level of evidence 2A).

Added Antiviral Treatment of Hepatitis B Virus (HBV)-related Hepatocellular Carcinoma as a new subsection.

Added text to state that chemotherapy followed by transarterial chemoembolization (TACE) followed by high-intensity focused ultrasound showed promising results in China for PRETEXT III and IV patients, some of whom were resectable but did not undergo surgery because of parent refusal (cited Wang et al. as reference 40).

1 | 2
Next Article:

Today on WebMD

Colorectal cancer cells
New! I AM Not Cancer Facebook Group
Lung cancer xray
See it in pictures, plus read the facts.
sauteed cherry tomatoes
Fight cancer one plate at a time.
Ovarian cancer illustration
Real Cancer Perspectives
Jennifer Goodman Linn self-portrait
what is your cancer risk
colorectal cancer treatment advances
breast cancer overview slideshow
prostate cancer overview
lung cancer overview slideshow
ovarian cancer overview slideshow
Actor Michael Douglas