The COG study COG-AHEP0731 (Combination Chemotherapy in Treating Children With Newly Diagnosed Hepatoblastoma) incorporates the following risk groups:
Very low risk
Stage I tumor with pure fetal histology and an alpha-fetoprotein (AFP) level greater than 100 ng/ml.
Stage I and II tumors and no small cell undifferentiated elements and an AFP level greater than 100 ng/ml.
Gross residual disease or unresectable disease.
Grossly resected disease with small cell undifferentiated elements.
AFP level must be greater than 100 ng/ml.
Any patient with metastases.
Any patient with initial AFP level less than 100 ng/ml, regardless of stage.
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