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    Childhood Liver Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Childhood Liver Cancer

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    Treatment of stage III hepatocellular carcinoma and PRETEXT stage 4 hepatocellular carcinoma may include the following:

    • Chemotherapy to shrink the tumor, followed by surgery to remove the tumor.
    • Chemotherapy to shrink the tumor. If surgery to completely remove the tumor is not possible, further treatment may include the following:
      • Liver transplant.
      • Cryosurgery.
      • Percutaneous ethanol injection.
      • Chemoembolization of the hepatic artery to shrink the tumor, followed by surgery to remove as much of the tumor as possible.
      • Radiation therapy.

    Treatment of stage IV hepatocellular carcinoma that was staged after surgery may include the following:

    • Combination chemotherapy to shrink the tumor, followed by surgery to remove as much of the tumor as possible.

    For children with advanced hepatocellular carcinoma, radioembolization may be used to relieve symptoms and improve quality of life.

    Antiviral drugs that treat infection caused by the hepatitis B virus have also been used in the treatment of hepatocellular carcinoma.

    Undifferentiated Embryonal Sarcoma of the Liver

    Treatment of undifferentiated embryonal sarcoma of the liver may include the following:

    • Combination chemotherapy to shrink the tumor, followed by surgery to remove as much of the tumor as possible.
    • A biopsy or surgery to remove the tumor followed by chemotherapy. A second surgery may be done to remove tumor that remains, followed by more chemotherapy.
    • Liver transplant if surgery to remove the tumor is not possible.

    Infantile Choriocarcinoma of the Liver

    Treatment of choriocarcinoma of the liver in infants may include the following:

    • Combination chemotherapy to shrink the tumor, followed by surgery to remove the tumor.

    Recurrent Childhood Liver Cancer

    Treatment of recurrent hepatoblastoma may include the following:

    • Combination chemotherapy.
    • Surgery to remove isolated (single and separate) metastatic tumors.
    • Liver transplant.
    • A clinical trial of a new treatment.

    Treatment of recurrent hepatocellular carcinoma may include the following:

    • Chemoembolization of the hepatic artery to shrink the tumor.
    • Liver transplant.
    • A clinical trial of a new treatment.

    Treatment Options in Clinical Trials

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood liver cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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