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Changes to This Summary (04 / 01 / 2013)


    Added text to state that the International Society of Pediatric Oncology Malignant Mesenchymal Tumor group found that RT improved local control in patients with localized pelvic rhabdomyosarcoma whose initial surgical procedure was biopsy only, leaving macroscopic residual tumor. Age older than 10 years and lymph node involvement were unfavorable prognostic factors (cited Réguerre et al. as reference 73 and level of evidence 2A).

    Added text to state that the Soft Tissue Sarcoma Committee of the COG recommends that RT be administered to patients with residual viable vaginal tumor, beginning at week 24.

    Added text to state that 12 of 14 girls with primary cervical embryonal rhabdomyosarcoma were disease-free following VAC chemotherapy and conservative surgery; of note, two girls also had a pleuropulmonary blastoma and another had Sertoli-Leydig cell tumor (cited Dehner et al. as reference 98).

    Added text to state that in a European trial of 457 patients with incompletely resected embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma, undifferentiated sarcoma, or soft tissue primitive neuroectodermal tumor, the addition of carboplatin, epirubicin, and etoposide to standard ifosfamide, vincristine, and dactinomycin therapy did not improve outcome (cited Oberlin et al. as reference 118).

    Added text to state that the pilot 1 and pilot 3 studies of the COG-ARST08P1 trial are now closed.

    This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: February 25, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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