After a gastrointestinal stromal tumor has been diagnosed, tests are done to find out if cancer cells have spread within the gastrointestinal tract or to other parts of the body.
The process used to find out if cancer has spread within the gastrointestinal (GI) tract or to other parts of the body is called staging. The information gathered from the staging process determines the stage of the disease. The following tests and procedures may be used in the staging process:
Added text about a European trial of adults with completely resected soft tissue sarcoma who were randomly assigned to observation or adjuvant chemotherapy with ifosfamide and doxorubicin, using a relatively low dose of ifosfamide. Adjuvant chemotherapy was not associated with improved event-free survival or overall survival; when the authors merged their patients with previously published series, they concluded that the results suggested a benefit for adjuvant chemotherapy (cited Woll et al. as reference 30 and level of evidence 1iiA).
Treatment of Newly Diagnosed Childhood Soft Tissue Sarcoma
Added text to state that expression and genomic index prognostic signatures have been studied in synovial sarcoma; more complex genomic profiles, with greater rearrangement of the genome, are more common in adults than in younger patients with synovial sarcoma and are associated with a higher risk for metastasis (cited Lagarde et al. as reference 134).
Added text to state that angiosarcomas or lymphangiosarcomas may arise in a setting of benign vascular anomalies or vascular malformations (cited Al Dhaybi et al. and Rossi et al. as references 150 and 151, respectively).
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WebMD Public Information from the National Cancer Institute
September 04, 2014
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