A classification system has been developed by the National Cancer Institute's PDQ Adult Treatment Editorial Board to allow the ranking of human cancer treatment studies according to statistical strength of the study design and scientific strength of the treatment outcomes (i.e., endpoints) measured. This classification system has been adapted to allow the ranking of human studies of complementary and alternative medicine treatments for cancer. The purpose of classifying studies in this way is to...
Added text about a European trial of adults with completely resected soft tissue sarcoma who were randomly assigned to observation or adjuvant chemotherapy with ifosfamide and doxorubicin, using a relatively low dose of ifosfamide. Adjuvant chemotherapy was not associated with improved event-free survival or overall survival; when the authors merged their patients with previously published series, they concluded that the results suggested a benefit for adjuvant chemotherapy (cited Woll et al. as reference 30 and level of evidence 1iiA).
Treatment of Newly Diagnosed Childhood Soft Tissue Sarcoma
Added text to state that expression and genomic index prognostic signatures have been studied in synovial sarcoma; more complex genomic profiles, with greater rearrangement of the genome, are more common in adults than in younger patients with synovial sarcoma and are associated with a higher risk for metastasis (cited Lagarde et al. as reference 134).
Added text to state that angiosarcomas or lymphangiosarcomas may arise in a setting of benign vascular anomalies or vascular malformations (cited Al Dhaybi et al. and Rossi et al. as references 150 and 151, respectively).
This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.
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WebMD Public Information from the National Cancer Institute
September 04, 2014
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