Langerhans cell histiocytosis is a disease that can damage tissue or cause lesions to form in one or more places in the body.
Langerhans cell histiocytosis (LCH) is a rare disease that begins in LCH cells (a type of dendritic cell which fights infection). Sometimes there are changes in LCH cells as they form. These changes may cause the LCH cells to grow and multiply quickly. This causes the LCH cells to build up in certain parts of the body, where they can damage tissue or form lesions.
Added text about a European trial of adults with completely resected soft tissue sarcoma who were randomly assigned to observation or adjuvant chemotherapy with ifosfamide and doxorubicin, using a relatively low dose of ifosfamide. Adjuvant chemotherapy was not associated with improved event-free survival or overall survival; when the authors merged their patients with previously published series, they concluded that the results suggested a benefit for adjuvant chemotherapy (cited Woll et al. as reference 30 and level of evidence 1iiA).
Treatment of Newly Diagnosed Childhood Soft Tissue Sarcoma
Added text to state that expression and genomic index prognostic signatures have been studied in synovial sarcoma; more complex genomic profiles, with greater rearrangement of the genome, are more common in adults than in younger patients with synovial sarcoma and are associated with a higher risk for metastasis (cited Lagarde et al. as reference 134).
Added text to state that angiosarcomas or lymphangiosarcomas may arise in a setting of benign vascular anomalies or vascular malformations (cited Al Dhaybi et al. and Rossi et al. as references 150 and 151, respectively).
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WebMD Public Information from the National Cancer Institute
September 04, 2014
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