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Childhood Soft Tissue Sarcoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Childhood Soft Tissue Sarcoma

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For treatment of plexiform histiocytic tumor

Treatment of plexiform histiocytic tumor is surgery to completely remove the tumor.

For treatment of synovial sarcoma

Treatment of synovial sarcoma may include the following:

  • Surgery with or without chemotherapy.
  • Chemotherapy.

For treatment of undifferentiated soft tissue sarcoma

There is no standard treatment for undifferentiated soft tissue sarcoma. Treatment may be within a clinical trial for patients with nonrhabdomyosarcomatous soft tissue sarcomas (NRSTS).

For treatment of angiosarcoma and lymphangiosarcoma

Treatment of angiosarcoma and lymphangiosarcoma may include the following:

  • Surgery to completely remove the tumor.
  • Radiation therapy or chemotherapy after surgery.

For treatment of hemangioendothelioma

Treatment of hemangioendothelioma in children younger than one year may include the following:

  • Watchful waiting as some tumors will disappear without treatment.
  • Treatment for blood clotting disorders.
  • Surgery to remove the tumor if there are symptoms.
  • Liver transplant (if the tumor is in the liver).

Treatment of hemangioendothelioma in children aged one year and older may include the following:

  • Surgery to remove the tumor.
  • Treatment for blood clotting disorders.
  • Liver transplant (if the tumor is in the liver).

For treatment of aggressive fibromatosis, dermatofibrosarcoma, and angiomatoid malignant fibrous histiocytoma

Treatment of these tumor types will be surgery whenever possible. Other treatments may include the following:

  • Targeted drug therapy with imatinib (Gleevec).
  • Radiation therapy after surgery.

For treatment of epithelioid sarcoma, leiomyosarcoma, liposarcoma, and mesenchymal chondrosarcoma

Treatment of these tumor types will be surgery whenever possible. Other treatments may include the following:

  • Chemotherapy followed by radiation therapy, surgery, or both.
  • Radiation therapy or chemotherapy after surgery.
  • A clinical trial of internal radiation therapy.
  • A clinical trial of radiation therapy given during surgery.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with nonmetastatic childhood soft tissue sarcoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Metastatic Childhood Soft Tissue Sarcoma

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