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Chronic Lymphocytic Leukemia Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (04 / 19 / 2013)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Stage I, II, III, and IV Chronic Lymphocytic Leukemia

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Revised text to state that the surrogate endpoint of such clearance of residual disease, while prognostic, has not been shown to improve survival in a randomized prospective trial.

Revised text in the third treatment option to state that a trial of 138 patients, who were previously treated with fludarabine and alemtuzumab, showed overall response rates around 50% in patients refractory to fludarabine and with prior exposure to rituximab (cited Wierda et al. as reference 14).

Added text to include lenalidomide as a treatment option and stated that it is an oral immunomodulatory agent with response rates over 50% for patients with previously treated and untreated disease (cited Chen et al., Chanan-Khan et al., and Ferrajoli et al. as references 34, 35, and 36, respectively, and Badoux et al. as reference 37 and level of evidence 3iiiDiv). Also added that prolonged, lower-dose approaches and attention to prevention of tumor lysis syndrome are recommended with this agent (cited Moutouh-de Parseval et al. as reference 38). Combination therapy and long-term toxicities from using lenalidomide remain undefined for patients with chronic lymphocytic leukemia.

This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: September 04, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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