Approximately 1.6 million new cases of cancer are expected to be diagnosed in the United States in 2013. Many patients diagnosed with cancer will eventually require support from a family caregiver. In fact, family caregivers form the foundation of the health care system in the United States, supporting advances in treatment such as multimodality treatment protocols given in outpatient and home settings.
Definition: Who Is the Caregiver?
Also referred to as informal caregivers, family...
Revised text to state that the surrogate endpoint of such clearance of residual disease, while prognostic, has not been shown to improve survival in a randomized prospective trial.
Revised text in the third treatment option to state that a trial of 138 patients, who were previously treated with fludarabine and alemtuzumab, showed overall response rates around 50% in patients refractory to fludarabine and with prior exposure to rituximab (cited Wierda et al. as reference 14).
Added text to include lenalidomide as a treatment option and stated that it is an oral immunomodulatory agent with response rates over 50% for patients with previously treated and untreated disease (cited Chen et al., Chanan-Khan et al., and Ferrajoli et al. as references 34, 35, and 36, respectively, and Badoux et al. as reference 37 and level of evidence 3iiiDiv). Also added that prolonged, lower-dose approaches and attention to prevention of tumor lysis syndrome are recommended with this agent (cited Moutouh-de Parseval et al. as reference 38). Combination therapy and long-term toxicities from using lenalidomide remain undefined for patients with chronic lymphocytic leukemia.
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WebMD Public Information from the National Cancer Institute
September 04, 2014
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