Major pharmaceutical companies continually research and develop new cancer drugs and treatments, which must be shown to be safe and effective before doctors can prescribe them to patients. Through lymphomaclinical trials, researchers test the effects of new medications on a group of volunteers with lymphoma. Following a strict protocol and using carefully controlled conditions, researchers evaluate the drugs under development and measure the ability of the new drug to treat lymphoma, its safety,...
Added text to state that nilotinib-treated patients had a lower rate of treatment-emergent BCR/ABL mutations than did imatinib-treated patients (cited Hochhaus et al. as reference 8).
Added text to state that a single-center, retrospective analysis of 483 patients with chronic phase CML who were treated with imatinib, dasatinib, or nilotinib indicated that patients who have better than 35% t(9;22)+ cells at 3 months of therapy have inferior event-free, transformation-free, and overall survival rates compared with patients who have better early cytogenetic responses (cited Jain et al. as reference 23).
Added Tyrosine kinase inhibitor-resistant CML as a new subsection.
Relapsing Chronic Myelogenous Leukemia (CML)
Added Jain et al. as reference 4.
Added text to state that for patients resistant to the tyrosine kinase inhibitors, omacetaxine mepesuccinate has shown a hematologic response rate of 67% and a median progression-free survival of 7 months in a small, phase II study of 46 patients (cited Cortes et al. as reference 21 and level of evidence 3iiiDiv).
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May 28, 2015
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