ALL (also called acute lymphocytic leukemia) is an aggressive type of leukemia characterized by the presence of too many lymphoblasts or lymphocytes in the bone marrow and peripheral blood. It can spread to the lymph nodes, spleen, liver, central nervous system (CNS), and other organs. Without treatment, ALL usually progresses quickly.
Signs and symptoms of ALL may include the following:
Weakness or fatigue.
Fever or night sweats.
Bruises or bleeds easily (i.e., bleeding gums, purplish...
Added text to state that nilotinib-treated patients had a lower rate of treatment-emergent BCR/ABL mutations than did imatinib-treated patients (cited Hochhaus et al. as reference 8).
Added text to state that a single-center, retrospective analysis of 483 patients with chronic phase CML who were treated with imatinib, dasatinib, or nilotinib indicated that patients who have better than 35% t(9;22)+ cells at 3 months of therapy have inferior event-free, transformation-free, and overall survival rates compared with patients who have better early cytogenetic responses (cited Jain et al. as reference 23).
Added Tyrosine kinase inhibitor-resistant CML as a new subsection.
Relapsing Chronic Myelogenous Leukemia (CML)
Added Jain et al. as reference 4.
Added text to state that for patients resistant to the tyrosine kinase inhibitors, omacetaxine mepesuccinate has shown a hematologic response rate of 67% and a median progression-free survival of 7 months in a small, phase II study of 46 patients (cited Cortes et al. as reference 21 and level of evidence 3iiiDiv).
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WebMD Public Information from the National Cancer Institute
May 28, 2015
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