Bone marrow is a spongy material inside your bones where your body makes and stores blood cells. When it’s damaged, it makes too few blood cells and not enough cells for your immune system.
A transplant replaces damaged bone marrow with healthy marrow cells. It can cure certain diseases or some types of cancer. It also means a long recovery process and a risk of serious side effects. If you’re thinking about having one, talk with your doctor about all the pros and cons of the transplant.
Added text to state that nilotinib-treated patients had a lower rate of treatment-emergent BCR/ABL mutations than did imatinib-treated patients (cited Hochhaus et al. as reference 8).
Added text to state that a single-center, retrospective analysis of 483 patients with chronic phase CML who were treated with imatinib, dasatinib, or nilotinib indicated that patients who have better than 35% t(9;22)+ cells at 3 months of therapy have inferior event-free, transformation-free, and overall survival rates compared with patients who have better early cytogenetic responses (cited Jain et al. as reference 23).
Added Tyrosine kinase inhibitor-resistant CML as a new subsection.
Relapsing Chronic Myelogenous Leukemia (CML)
Added Jain et al. as reference 4.
Added text to state that for patients resistant to the tyrosine kinase inhibitors, omacetaxine mepesuccinate has shown a hematologic response rate of 67% and a median progression-free survival of 7 months in a small, phase II study of 46 patients (cited Cortes et al. as reference 21 and level of evidence 3iiiDiv).
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May 28, 2015
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